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Unlocking Asymmetric Michael Additions in an Archetypical Class I Aldolase by Directed Evolution

[Image: see text] Class I aldolases catalyze asymmetric aldol addition reactions and have found extensive application in the biocatalytic synthesis of chiral β-hydroxy-carbonyl compounds. However, the usefulness of these powerful enzymes for application in other C–C bond-forming reactions remains th...

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Detalles Bibliográficos
Autores principales:	Kunzendorf, Andreas, Xu, Guangcai, van der Velde, Jesse J. H., Rozeboom, Henriëtte J., Thunnissen, Andy-Mark W. H., Poelarends, Gerrit J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576802/ https://www.ncbi.nlm.nih.gov/pubmed/34765282 http://dx.doi.org/10.1021/acscatal.1c03911

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