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In Silico Identification and Experimental Validation of Distal Activity-Enhancing Mutations in Tryptophan Synthase

[Image: see text] Allostery is a central mechanism for the regulation of multi-enzyme complexes. The mechanistic basis that drives allosteric regulation is poorly understood but harbors key information for enzyme engineering. In the present study, we focus on the tryptophan synthase complex that is...

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Detalles Bibliográficos
Autores principales:	Maria-Solano, Miguel A., Kinateder, Thomas, Iglesias-Fernández, Javier, Sterner, Reinhard, Osuna, Sílvia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576815/ https://www.ncbi.nlm.nih.gov/pubmed/34777912 http://dx.doi.org/10.1021/acscatal.1c03950

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