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Cancer cell-derived exosomal circUSP7 induces CD8(+) T cell dysfunction and anti-PD1 resistance by regulating the miR-934/SHP2 axis in NSCLC

BACKGROUND: CD8(+) T cells play a critical role in the innate antitumour immune response. Recently, CD8(+) T cell dysfunction has been verified in various malignant cancers, including non-small cell lung cancer (NSCLC). However, the molecular biological mechanisms of CD8(+) T cell dysfunction in hum...

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Detalles Bibliográficos
Autores principales:	Chen, Shi-Wei, Zhu, Shu-Qiang, Pei, Xu, Qiu, Bai-Quan, Xiong, Dian, Long, Xiang, Lin, Kun, Lu, Feng, Xu, Jian-Jun, Wu, Yong-Bing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576933/ https://www.ncbi.nlm.nih.gov/pubmed/34753486 http://dx.doi.org/10.1186/s12943-021-01448-x

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