Functional pre-therapeutic evaluation by genome editing of variants of uncertain significance of essential tumor suppressor genes

BACKGROUND: Targeted therapies in oncology are promising but variants of uncertain significance (VUS) limit their use for clinical management and necessitate functional testing in vitro. Using BRCA1 and BRCA2 variants, which have consequences on PARP inhibitor sensitivity, and POLE variants, potenti...

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Detalles Bibliográficos
Autores principales: Billaud, Amandine, Chevalier, Louise-Marie, Augereau, Paule, Frenel, Jean-Sebastien, Passot, Christophe, Campone, Mario, Morel, Alain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576946/
https://www.ncbi.nlm.nih.gov/pubmed/34749799
http://dx.doi.org/10.1186/s13073-021-00976-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576946/
https://www.ncbi.nlm.nih.gov/pubmed/34749799
http://dx.doi.org/10.1186/s13073-021-00976-x

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