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Dynamic regulation of mitochondrial pyruvate metabolism is necessary for orthotopic pancreatic tumor growth

BACKGROUND: Pyruvate dehydrogenase complex (PDC) plays a central role in carbohydrate metabolism, linking cytoplasmic glycolysis to the mitochondrial tricarboxylic acid (TCA) cycle. PDC is a conserved E1-E2-E3 dehydrogenase with a PDHA1 and PDHB heterotetramer functioning as the E1 subunit. PDHA1 co...

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Detalles Bibliográficos
Autores principales:	Echeverri Ruiz, Nancy P., Mohan, Vijay, Wu, Jinghai, Scott, Sabina, Kreamer, McKenzie, Benej, Martin, Golias, Tereza, Papandreou, Ioanna, Denko, Nicholas C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577026/ https://www.ncbi.nlm.nih.gov/pubmed/34749809 http://dx.doi.org/10.1186/s40170-021-00275-4

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