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Intrinsic Functional Connectivity of the Anterior Cingulate Cortex Is Associated with Tolerance to Distress
The ability to adapt under significant adversity, defined as psychological resilience, is instrumental in preventing stress-related disorders. An important aspect of resilience is the capacity to endure affective distress when in pursuit of goals, also known as distress tolerance. Evidence that link...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Society for Neuroscience
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577043/ https://www.ncbi.nlm.nih.gov/pubmed/34593518 http://dx.doi.org/10.1523/ENEURO.0277-21.2021 |
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author | Dezachyo, Or Kozak, Stas Bar-Haim, Yair Censor, Nitzan Dayan, Eran |
author_facet | Dezachyo, Or Kozak, Stas Bar-Haim, Yair Censor, Nitzan Dayan, Eran |
author_sort | Dezachyo, Or |
collection | PubMed |
description | The ability to adapt under significant adversity, defined as psychological resilience, is instrumental in preventing stress-related disorders. An important aspect of resilience is the capacity to endure affective distress when in pursuit of goals, also known as distress tolerance. Evidence that links intrinsic baseline interactions within large-scale functional networks with performance under distress remains missing. We hypothesized that the anterior cingulate cortex (ACC) may engage in distress tolerance because of its involvement in attention and emotion regulation. Accordingly, we tested whether behavioral performance under distress is associated with baseline resting-state ACC functional connectivity (FC). Distress tolerance was measured in 97 participants using the behavioral indicator of resiliency to distress (BIRD) task. Analyses contrasted participants who quit the task before its designated termination (n = 51) with those who persisted throughout it (n = 46). Seed-based FC analysis indicated greater connectivity between the ACC and dorsolateral prefrontal cortex (DLPFC) in subjects who persisted throughout the task, along with greater FC between the ACC and the precentral gyrus in those who quit before its termination. The results shed light on the mechanisms underlying interindividual differences in the ability to handle distress. |
format | Online Article Text |
id | pubmed-8577043 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Society for Neuroscience |
record_format | MEDLINE/PubMed |
spelling | pubmed-85770432021-11-09 Intrinsic Functional Connectivity of the Anterior Cingulate Cortex Is Associated with Tolerance to Distress Dezachyo, Or Kozak, Stas Bar-Haim, Yair Censor, Nitzan Dayan, Eran eNeuro Research Article: New Research The ability to adapt under significant adversity, defined as psychological resilience, is instrumental in preventing stress-related disorders. An important aspect of resilience is the capacity to endure affective distress when in pursuit of goals, also known as distress tolerance. Evidence that links intrinsic baseline interactions within large-scale functional networks with performance under distress remains missing. We hypothesized that the anterior cingulate cortex (ACC) may engage in distress tolerance because of its involvement in attention and emotion regulation. Accordingly, we tested whether behavioral performance under distress is associated with baseline resting-state ACC functional connectivity (FC). Distress tolerance was measured in 97 participants using the behavioral indicator of resiliency to distress (BIRD) task. Analyses contrasted participants who quit the task before its designated termination (n = 51) with those who persisted throughout it (n = 46). Seed-based FC analysis indicated greater connectivity between the ACC and dorsolateral prefrontal cortex (DLPFC) in subjects who persisted throughout the task, along with greater FC between the ACC and the precentral gyrus in those who quit before its termination. The results shed light on the mechanisms underlying interindividual differences in the ability to handle distress. Society for Neuroscience 2021-10-13 /pmc/articles/PMC8577043/ /pubmed/34593518 http://dx.doi.org/10.1523/ENEURO.0277-21.2021 Text en Copyright © 2021 Dezachyo et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
spellingShingle | Research Article: New Research Dezachyo, Or Kozak, Stas Bar-Haim, Yair Censor, Nitzan Dayan, Eran Intrinsic Functional Connectivity of the Anterior Cingulate Cortex Is Associated with Tolerance to Distress |
title | Intrinsic Functional Connectivity of the Anterior Cingulate Cortex Is Associated with Tolerance to Distress |
title_full | Intrinsic Functional Connectivity of the Anterior Cingulate Cortex Is Associated with Tolerance to Distress |
title_fullStr | Intrinsic Functional Connectivity of the Anterior Cingulate Cortex Is Associated with Tolerance to Distress |
title_full_unstemmed | Intrinsic Functional Connectivity of the Anterior Cingulate Cortex Is Associated with Tolerance to Distress |
title_short | Intrinsic Functional Connectivity of the Anterior Cingulate Cortex Is Associated with Tolerance to Distress |
title_sort | intrinsic functional connectivity of the anterior cingulate cortex is associated with tolerance to distress |
topic | Research Article: New Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577043/ https://www.ncbi.nlm.nih.gov/pubmed/34593518 http://dx.doi.org/10.1523/ENEURO.0277-21.2021 |
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