Loss of FBXO31-mediated degradation of DUSP6 dysregulates ERK and PI3K-AKT signaling and promotes prostate tumorigenesis

FBXO31 is the substrate receptor of one of many CUL1-RING ubiquitin ligase (CRL1) complexes. Here, we show that low FBXO31 mRNA levels are associated with high pre-operative prostate-specific antigen (PSA) levels and Gleason grade in human prostate cancer. Mechanistically, the ubiquitin ligase CRL1(...

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Detalles Bibliográficos
Autores principales: Duan, Shanshan, Moro, Loredana, Qu, Rui, Simoneschi, Daniele, Cho, Hyunwoo, Jiang, Shaowen, Zhao, Huiyong, Chang, Qing, de Stanchina, Elisa, Arbini, Arnaldo A., Pagano, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577224/
https://www.ncbi.nlm.nih.gov/pubmed/34686346
http://dx.doi.org/10.1016/j.celrep.2021.109870

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