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Revisiting nocturnal heart rate and heart rate variability in insomnia: A polysomnography‐based comparison of young self‐reported good and poor sleepers
Primary insomnia is often considered a disorder of 24‐hr hyperarousal. Numerous attempts have been made to investigate nocturnal heart rate (HR) and its variability (HRV) as potential pathophysiological hallmarks of altered arousal levels in insomnia, with mixed results. We have aimed to overcome so...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577225/ https://www.ncbi.nlm.nih.gov/pubmed/33622029 http://dx.doi.org/10.1111/jsr.13278 |
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author | Cosgrave, Jan Phillips, Jessica Haines, Ross Foster, Russell G. Steinsaltz, David Wulff, Katharina |
author_facet | Cosgrave, Jan Phillips, Jessica Haines, Ross Foster, Russell G. Steinsaltz, David Wulff, Katharina |
author_sort | Cosgrave, Jan |
collection | PubMed |
description | Primary insomnia is often considered a disorder of 24‐hr hyperarousal. Numerous attempts have been made to investigate nocturnal heart rate (HR) and its variability (HRV) as potential pathophysiological hallmarks of altered arousal levels in insomnia, with mixed results. We have aimed to overcome some of the pitfalls of previous studies by using a young, medication‐free, age‐ and gender‐matched population consisting of 43 students aged 18–30 years half with a subthreshold insomnia complaint. We employed at‐home ambulatory polysomnography and compared this attenuated insomnia group to a good sleeping group. The poor sleepers had significantly higher wake after sleep onset, arousal count, mean HR in all sleep stages (with the exception of Stage 1) and lower sleep efficiency. Consistent with previous research, we also found a significant group‐by‐sleep stage interaction in the prediction of nocturnal HR, highlighting the insomnia group to have a lower wake–sleep HR reduction compared to good sleepers. When restricting our analyses to insomnia with objectively determined short sleep duration, we found significantly lower standard deviation of RR intervals (SDNN; a measure of HRV) compared to good sleepers. Taken together, this lends credence to the hyperarousal model of insomnia and may at least partially explain the increased prevalence of cardiovascular morbidity and mortality observed in patients with insomnia. |
format | Online Article Text |
id | pubmed-8577225 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85772252021-11-15 Revisiting nocturnal heart rate and heart rate variability in insomnia: A polysomnography‐based comparison of young self‐reported good and poor sleepers Cosgrave, Jan Phillips, Jessica Haines, Ross Foster, Russell G. Steinsaltz, David Wulff, Katharina J Sleep Res Insomnia Primary insomnia is often considered a disorder of 24‐hr hyperarousal. Numerous attempts have been made to investigate nocturnal heart rate (HR) and its variability (HRV) as potential pathophysiological hallmarks of altered arousal levels in insomnia, with mixed results. We have aimed to overcome some of the pitfalls of previous studies by using a young, medication‐free, age‐ and gender‐matched population consisting of 43 students aged 18–30 years half with a subthreshold insomnia complaint. We employed at‐home ambulatory polysomnography and compared this attenuated insomnia group to a good sleeping group. The poor sleepers had significantly higher wake after sleep onset, arousal count, mean HR in all sleep stages (with the exception of Stage 1) and lower sleep efficiency. Consistent with previous research, we also found a significant group‐by‐sleep stage interaction in the prediction of nocturnal HR, highlighting the insomnia group to have a lower wake–sleep HR reduction compared to good sleepers. When restricting our analyses to insomnia with objectively determined short sleep duration, we found significantly lower standard deviation of RR intervals (SDNN; a measure of HRV) compared to good sleepers. Taken together, this lends credence to the hyperarousal model of insomnia and may at least partially explain the increased prevalence of cardiovascular morbidity and mortality observed in patients with insomnia. John Wiley and Sons Inc. 2021-02-23 2021-08 /pmc/articles/PMC8577225/ /pubmed/33622029 http://dx.doi.org/10.1111/jsr.13278 Text en © 2021 The Authors. Journal of Sleep Research published by John Wiley & Sons Ltd on behalf of European Sleep Research Society. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Insomnia Cosgrave, Jan Phillips, Jessica Haines, Ross Foster, Russell G. Steinsaltz, David Wulff, Katharina Revisiting nocturnal heart rate and heart rate variability in insomnia: A polysomnography‐based comparison of young self‐reported good and poor sleepers |
title | Revisiting nocturnal heart rate and heart rate variability in insomnia: A polysomnography‐based comparison of young self‐reported good and poor sleepers |
title_full | Revisiting nocturnal heart rate and heart rate variability in insomnia: A polysomnography‐based comparison of young self‐reported good and poor sleepers |
title_fullStr | Revisiting nocturnal heart rate and heart rate variability in insomnia: A polysomnography‐based comparison of young self‐reported good and poor sleepers |
title_full_unstemmed | Revisiting nocturnal heart rate and heart rate variability in insomnia: A polysomnography‐based comparison of young self‐reported good and poor sleepers |
title_short | Revisiting nocturnal heart rate and heart rate variability in insomnia: A polysomnography‐based comparison of young self‐reported good and poor sleepers |
title_sort | revisiting nocturnal heart rate and heart rate variability in insomnia: a polysomnography‐based comparison of young self‐reported good and poor sleepers |
topic | Insomnia |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577225/ https://www.ncbi.nlm.nih.gov/pubmed/33622029 http://dx.doi.org/10.1111/jsr.13278 |
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