Pd-catalyzed allylative dearomatisation using Grignard reagents

Pd-catalyzed allylative dearomatisation of naphthyl halides is shown to be feasible by employing Grignard reagents. The high reactivity of the nucleophile allows for fast reactions and low catalyst loading, while a plethora of successfully substituted compounds illustrate the broad scope. Five membe...

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Detalles Bibliográficos
Autores principales: Boldrini, Cosimo, Harutyunyan, Syuzanna R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577247/
https://www.ncbi.nlm.nih.gov/pubmed/34693941
http://dx.doi.org/10.1039/d1cc05609c
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author Boldrini, Cosimo
Harutyunyan, Syuzanna R.
author_facet Boldrini, Cosimo
Harutyunyan, Syuzanna R.
author_sort Boldrini, Cosimo
collection PubMed
description Pd-catalyzed allylative dearomatisation of naphthyl halides is shown to be feasible by employing Grignard reagents. The high reactivity of the nucleophile allows for fast reactions and low catalyst loading, while a plethora of successfully substituted compounds illustrate the broad scope. Five membered heteroaromatic compounds are also demonstrated to be reactive under similar conditions.
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spelling pubmed-85772472021-12-13 Pd-catalyzed allylative dearomatisation using Grignard reagents Boldrini, Cosimo Harutyunyan, Syuzanna R. Chem Commun (Camb) Chemistry Pd-catalyzed allylative dearomatisation of naphthyl halides is shown to be feasible by employing Grignard reagents. The high reactivity of the nucleophile allows for fast reactions and low catalyst loading, while a plethora of successfully substituted compounds illustrate the broad scope. Five membered heteroaromatic compounds are also demonstrated to be reactive under similar conditions. The Royal Society of Chemistry 2021-10-25 /pmc/articles/PMC8577247/ /pubmed/34693941 http://dx.doi.org/10.1039/d1cc05609c Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Boldrini, Cosimo
Harutyunyan, Syuzanna R.
Pd-catalyzed allylative dearomatisation using Grignard reagents
title Pd-catalyzed allylative dearomatisation using Grignard reagents
title_full Pd-catalyzed allylative dearomatisation using Grignard reagents
title_fullStr Pd-catalyzed allylative dearomatisation using Grignard reagents
title_full_unstemmed Pd-catalyzed allylative dearomatisation using Grignard reagents
title_short Pd-catalyzed allylative dearomatisation using Grignard reagents
title_sort pd-catalyzed allylative dearomatisation using grignard reagents
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577247/
https://www.ncbi.nlm.nih.gov/pubmed/34693941
http://dx.doi.org/10.1039/d1cc05609c
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