The role of retinoic acid in the commitment to meiosis

Male meiosis is a complex process whereby spermatocytes undergo cell division to form haploid cells. This review focuses on the role of retinoic acid (RA) in meiosis, as well as several processes regulated by RA before cell entry into meiosis that are critical for proper meiotic entry and completion...

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Autores principales: Gewiss, Rachel L., Schleif, M Christine, Griswold, Michael D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Invited Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577254/
https://www.ncbi.nlm.nih.gov/pubmed/34472453
http://dx.doi.org/10.4103/aja202156
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author Gewiss, Rachel L.
Schleif, M Christine
Griswold, Michael D
author_facet Gewiss, Rachel L.
Schleif, M Christine
Griswold, Michael D
author_sort Gewiss, Rachel L.
collection PubMed
description Male meiosis is a complex process whereby spermatocytes undergo cell division to form haploid cells. This review focuses on the role of retinoic acid (RA) in meiosis, as well as several processes regulated by RA before cell entry into meiosis that are critical for proper meiotic entry and completion. Here, we discuss RA metabolism in the testis as well as the roles of stimulated by retinoic acid gene 8 (STRA8) and MEIOSIN, which are responsive to RA and are critical for meiosis. We assert that transcriptional regulation in the spermatogonia is critical for successful meiosis.
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spelling pubmed-85772542021-11-10 The role of retinoic acid in the commitment to meiosis Gewiss, Rachel L. Schleif, M Christine Griswold, Michael D Asian J Androl Invited Review Male meiosis is a complex process whereby spermatocytes undergo cell division to form haploid cells. This review focuses on the role of retinoic acid (RA) in meiosis, as well as several processes regulated by RA before cell entry into meiosis that are critical for proper meiotic entry and completion. Here, we discuss RA metabolism in the testis as well as the roles of stimulated by retinoic acid gene 8 (STRA8) and MEIOSIN, which are responsive to RA and are critical for meiosis. We assert that transcriptional regulation in the spermatogonia is critical for successful meiosis. Wolters Kluwer - Medknow 2021-08-27 /pmc/articles/PMC8577254/ /pubmed/34472453 http://dx.doi.org/10.4103/aja202156 Text en Copyright: © The Author(s)(2021) https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Invited Review
Gewiss, Rachel L.
Schleif, M Christine
Griswold, Michael D
The role of retinoic acid in the commitment to meiosis
title The role of retinoic acid in the commitment to meiosis
title_full The role of retinoic acid in the commitment to meiosis
title_fullStr The role of retinoic acid in the commitment to meiosis
title_full_unstemmed The role of retinoic acid in the commitment to meiosis
title_short The role of retinoic acid in the commitment to meiosis
title_sort role of retinoic acid in the commitment to meiosis
topic Invited Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577254/
https://www.ncbi.nlm.nih.gov/pubmed/34472453
http://dx.doi.org/10.4103/aja202156
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