CRISPR/Cas9 Ablation of Integrated HIV-1 Accumulates Proviral DNA Circles with Reformed Long Terminal Repeats

Gene editing may be used to excise the human immunodeficiency virus type 1 (HIV-1) provirus from the host cell genome, possibly eradicating the infection. Here, using cells acutely or latently infected by HIV-1 and treated with long terminal repeat (LTR)-targeting CRISPR/Cas9, we show that the excis...

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Detalles Bibliográficos
Autores principales: Lai, Michele, Maori, Eyal, Quaranta, Paola, Matteoli, Giulia, Maggi, Fabrizio, Sgarbanti, Marco, Crucitta, Stefania, Pacini, Simone, Turriziani, Ombretta, Antonelli, Guido, Heeney, Jonathan L., Freer, Giulia, Pistello, Mauro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Virus-Cell Interactions
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577360/
https://www.ncbi.nlm.nih.gov/pubmed/34549986
http://dx.doi.org/10.1128/JVI.01358-21

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