Metformin reduces macrophage HIF1α-dependent proinflammatory signaling to restore brown adipocyte function in vitro

Therapeutic potential of metformin in obese/diabetic patients has been associated to its ability to combat insulin resistance. However, it remains largely unknown the signaling pathways involved and whether some cell types are particularly relevant for its beneficial effects. M1-activation of macrop...

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Detalles Bibliográficos
Autores principales: Pescador, Nuria, Francisco, Vera, Vázquez, Patricia, Esquinas, Eva María, González-Páramos, Cristina, Valdecantos, M. Pilar, García-Martínez, Irma, Urrutia, Andrés A., Ruiz, Laura, Escalona-Garrido, Carmen, Foretz, Marc, Viollet, Benoit, Fernández-Moreno, Miguel Ángel, Calle-Pascual, Alfonso L., Obregón, María Jesús, Aragonés, Julián, Valverde, Ángela M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577482/
https://www.ncbi.nlm.nih.gov/pubmed/34736121
http://dx.doi.org/10.1016/j.redox.2021.102171

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