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Epidural Spinal Electrogram Provides Direct Spinal Recordings in Awake Human Participants

Little is known about the electrophysiological activity of the spinal cord during voluntary movement control in humans. We present a novel method for recording electrophysiological activity from the human spinal cord using implanted epidural electrodes during naturalistic movements including overgro...

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Autores principales: Burke, John F., Kunwar, Nikhita, Yaroshinsky, Maria S., Louie, Kenneth H., Shirvalkar, Prasad, Su, Paul, Henry, Melanie, Pasvankas, George, Poree, Lawrence, Jacques, Lines, Wang, Doris D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577539/
https://www.ncbi.nlm.nih.gov/pubmed/34764858
http://dx.doi.org/10.3389/fnhum.2021.721076
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author Burke, John F.
Kunwar, Nikhita
Yaroshinsky, Maria S.
Louie, Kenneth H.
Shirvalkar, Prasad
Su, Paul
Henry, Melanie
Pasvankas, George
Poree, Lawrence
Jacques, Lines
Wang, Doris D.
author_facet Burke, John F.
Kunwar, Nikhita
Yaroshinsky, Maria S.
Louie, Kenneth H.
Shirvalkar, Prasad
Su, Paul
Henry, Melanie
Pasvankas, George
Poree, Lawrence
Jacques, Lines
Wang, Doris D.
author_sort Burke, John F.
collection PubMed
description Little is known about the electrophysiological activity of the spinal cord during voluntary movement control in humans. We present a novel method for recording electrophysiological activity from the human spinal cord using implanted epidural electrodes during naturalistic movements including overground walking. Spinal electrograms (SEGs) were recorded from epidural electrodes implanted as part of a test trial for patients with chronic pain undergoing evaluation for spinal cord stimulation. Externalized ends of the epidural leads were connected to an external amplifier to capture SEGs. Electromyographic and accelerometry data from the upper and lower extremities were collected using wireless sensors and synchronized to the SEG data. Patients were instructed to perform various arm and leg movements while SEG and kinematic data were collected. This study proves the safety and feasibility of performing epidural spinal recordings from human subjects performing movement tasks.
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spelling pubmed-85775392021-11-10 Epidural Spinal Electrogram Provides Direct Spinal Recordings in Awake Human Participants Burke, John F. Kunwar, Nikhita Yaroshinsky, Maria S. Louie, Kenneth H. Shirvalkar, Prasad Su, Paul Henry, Melanie Pasvankas, George Poree, Lawrence Jacques, Lines Wang, Doris D. Front Hum Neurosci Neuroscience Little is known about the electrophysiological activity of the spinal cord during voluntary movement control in humans. We present a novel method for recording electrophysiological activity from the human spinal cord using implanted epidural electrodes during naturalistic movements including overground walking. Spinal electrograms (SEGs) were recorded from epidural electrodes implanted as part of a test trial for patients with chronic pain undergoing evaluation for spinal cord stimulation. Externalized ends of the epidural leads were connected to an external amplifier to capture SEGs. Electromyographic and accelerometry data from the upper and lower extremities were collected using wireless sensors and synchronized to the SEG data. Patients were instructed to perform various arm and leg movements while SEG and kinematic data were collected. This study proves the safety and feasibility of performing epidural spinal recordings from human subjects performing movement tasks. Frontiers Media S.A. 2021-10-26 /pmc/articles/PMC8577539/ /pubmed/34764858 http://dx.doi.org/10.3389/fnhum.2021.721076 Text en Copyright © 2021 Burke, Kunwar, Yaroshinsky, Louie, Shirvalkar, Su, Henry, Pasvankas, Poree, Jacques and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Burke, John F.
Kunwar, Nikhita
Yaroshinsky, Maria S.
Louie, Kenneth H.
Shirvalkar, Prasad
Su, Paul
Henry, Melanie
Pasvankas, George
Poree, Lawrence
Jacques, Lines
Wang, Doris D.
Epidural Spinal Electrogram Provides Direct Spinal Recordings in Awake Human Participants
title Epidural Spinal Electrogram Provides Direct Spinal Recordings in Awake Human Participants
title_full Epidural Spinal Electrogram Provides Direct Spinal Recordings in Awake Human Participants
title_fullStr Epidural Spinal Electrogram Provides Direct Spinal Recordings in Awake Human Participants
title_full_unstemmed Epidural Spinal Electrogram Provides Direct Spinal Recordings in Awake Human Participants
title_short Epidural Spinal Electrogram Provides Direct Spinal Recordings in Awake Human Participants
title_sort epidural spinal electrogram provides direct spinal recordings in awake human participants
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577539/
https://www.ncbi.nlm.nih.gov/pubmed/34764858
http://dx.doi.org/10.3389/fnhum.2021.721076
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