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Population-level seropositivity trend for SARS-Cov-2 in Rio Grande do Sul, Brazil

OBJECTIVE: To describe the evolution of seropositivity in the State of Rio Grande do Sul, Brazil, through 10 consecutive surveys conducted between April 2020 and April 2021. METHODS: Nine cities covering all regions of the State were studied, 500 households in each city. One resident in each househo...

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Autores principales: Barros, Aluísio J D, Victora, Cesar G, Menezes, Ana M B, Horta, Bernardo L, Barros, Fernando C, Hartwig, Fernando P, Victora, Gabriel D, Vidaletti, Luis Paulo, Silveira, Mariângela F, Mesenburg, Marilia A, Jacques, Nadège, Struchiner, Cláudio J, Brust, Flávia Roberta, Dall’Agnol, Marinel M, Delamare, Ana Paula Longaray, François, Carlos Henrique R, Ikeda, Maria Letícia R, Pellegrini, Débora C P, Reuter, Cézane Priscila, da Silva, Shana G, Dellagostin, Odir A, Hallal, Pedro C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Faculdade de Saúde Pública da Universidade de São Paulo 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577540/
https://www.ncbi.nlm.nih.gov/pubmed/34816981
http://dx.doi.org/10.11606/s1518-8787.2021055004075
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author Barros, Aluísio J D
Victora, Cesar G
Menezes, Ana M B
Horta, Bernardo L
Barros, Fernando C
Hartwig, Fernando P
Victora, Gabriel D
Vidaletti, Luis Paulo
Silveira, Mariângela F
Mesenburg, Marilia A
Jacques, Nadège
Struchiner, Cláudio J
Brust, Flávia Roberta
Dall’Agnol, Marinel M
Delamare, Ana Paula Longaray
François, Carlos Henrique R
Ikeda, Maria Letícia R
Pellegrini, Débora C P
Reuter, Cézane Priscila
da Silva, Shana G
Dellagostin, Odir A
Hallal, Pedro C
author_facet Barros, Aluísio J D
Victora, Cesar G
Menezes, Ana M B
Horta, Bernardo L
Barros, Fernando C
Hartwig, Fernando P
Victora, Gabriel D
Vidaletti, Luis Paulo
Silveira, Mariângela F
Mesenburg, Marilia A
Jacques, Nadège
Struchiner, Cláudio J
Brust, Flávia Roberta
Dall’Agnol, Marinel M
Delamare, Ana Paula Longaray
François, Carlos Henrique R
Ikeda, Maria Letícia R
Pellegrini, Débora C P
Reuter, Cézane Priscila
da Silva, Shana G
Dellagostin, Odir A
Hallal, Pedro C
author_sort Barros, Aluísio J D
collection PubMed
description OBJECTIVE: To describe the evolution of seropositivity in the State of Rio Grande do Sul, Brazil, through 10 consecutive surveys conducted between April 2020 and April 2021. METHODS: Nine cities covering all regions of the State were studied, 500 households in each city. One resident in each household was randomly selected for testing. In survey rounds 1–8 we used the rapid WONDFO SARS-CoV-2 Antibody Test (Wondfo Biotech Co., Guangzhou, China). In rounds 9–10, we used a direct ELISA test that identifies IgG to the viral S protein (S-UFRJ). In terms of social distancing, individuals were asked three questions, from which we generated an exposure score using principal components analysis. RESULTS: Antibody prevalence in early April 2020 was 0.07%, increasing to 10.0% in February 2021, and to 18.2% in April 2021. In round 10, self-reported whites showed the lowest seroprevalence (17.3%), while indigenous individuals presented the highest (44.4%). Seropositivity increased by 40% when comparing the most with the least exposed. CONCLUSIONS: The proportion of the population already infected by SARS-Cov-2 in the state is still far from any perspective of herd immunity and the infection affects population groups in very different levels.
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spelling pubmed-85775402021-11-13 Population-level seropositivity trend for SARS-Cov-2 in Rio Grande do Sul, Brazil Barros, Aluísio J D Victora, Cesar G Menezes, Ana M B Horta, Bernardo L Barros, Fernando C Hartwig, Fernando P Victora, Gabriel D Vidaletti, Luis Paulo Silveira, Mariângela F Mesenburg, Marilia A Jacques, Nadège Struchiner, Cláudio J Brust, Flávia Roberta Dall’Agnol, Marinel M Delamare, Ana Paula Longaray François, Carlos Henrique R Ikeda, Maria Letícia R Pellegrini, Débora C P Reuter, Cézane Priscila da Silva, Shana G Dellagostin, Odir A Hallal, Pedro C Rev Saude Publica Original Article OBJECTIVE: To describe the evolution of seropositivity in the State of Rio Grande do Sul, Brazil, through 10 consecutive surveys conducted between April 2020 and April 2021. METHODS: Nine cities covering all regions of the State were studied, 500 households in each city. One resident in each household was randomly selected for testing. In survey rounds 1–8 we used the rapid WONDFO SARS-CoV-2 Antibody Test (Wondfo Biotech Co., Guangzhou, China). In rounds 9–10, we used a direct ELISA test that identifies IgG to the viral S protein (S-UFRJ). In terms of social distancing, individuals were asked three questions, from which we generated an exposure score using principal components analysis. RESULTS: Antibody prevalence in early April 2020 was 0.07%, increasing to 10.0% in February 2021, and to 18.2% in April 2021. In round 10, self-reported whites showed the lowest seroprevalence (17.3%), while indigenous individuals presented the highest (44.4%). Seropositivity increased by 40% when comparing the most with the least exposed. CONCLUSIONS: The proportion of the population already infected by SARS-Cov-2 in the state is still far from any perspective of herd immunity and the infection affects population groups in very different levels. Faculdade de Saúde Pública da Universidade de São Paulo 2021-11-08 /pmc/articles/PMC8577540/ /pubmed/34816981 http://dx.doi.org/10.11606/s1518-8787.2021055004075 Text en https://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Barros, Aluísio J D
Victora, Cesar G
Menezes, Ana M B
Horta, Bernardo L
Barros, Fernando C
Hartwig, Fernando P
Victora, Gabriel D
Vidaletti, Luis Paulo
Silveira, Mariângela F
Mesenburg, Marilia A
Jacques, Nadège
Struchiner, Cláudio J
Brust, Flávia Roberta
Dall’Agnol, Marinel M
Delamare, Ana Paula Longaray
François, Carlos Henrique R
Ikeda, Maria Letícia R
Pellegrini, Débora C P
Reuter, Cézane Priscila
da Silva, Shana G
Dellagostin, Odir A
Hallal, Pedro C
Population-level seropositivity trend for SARS-Cov-2 in Rio Grande do Sul, Brazil
title Population-level seropositivity trend for SARS-Cov-2 in Rio Grande do Sul, Brazil
title_full Population-level seropositivity trend for SARS-Cov-2 in Rio Grande do Sul, Brazil
title_fullStr Population-level seropositivity trend for SARS-Cov-2 in Rio Grande do Sul, Brazil
title_full_unstemmed Population-level seropositivity trend for SARS-Cov-2 in Rio Grande do Sul, Brazil
title_short Population-level seropositivity trend for SARS-Cov-2 in Rio Grande do Sul, Brazil
title_sort population-level seropositivity trend for sars-cov-2 in rio grande do sul, brazil
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577540/
https://www.ncbi.nlm.nih.gov/pubmed/34816981
http://dx.doi.org/10.11606/s1518-8787.2021055004075
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