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Treatment Outcomes and Clinical Relevance in Patients with Double Expressor DLBCL

BACKGROUND: Double-expressor lymphoma (DEL) was found to account for 20–30% of DLBCL. We conducted this study to analyze the survival, the clinical presentation, and the factors associated with treatment outcomes in DEL-DLBCL. METHODS: A retrospective study of 291 patients diagnosed with DLBCL durin...

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Detalles Bibliográficos
Autores principales: Rungwittayatiwat, Sirapat, Boonsakan, Paisarn, Chantrathammachart, Pichika, Puavilai, Teeraya, Pukiat, Sulada, Phusanti, Sithakom, Boonyawat, Kochawan, Wacharapornin, Pathawut, Angchaisuksiri, Pantep, Ungkanont, Artit, Chuncharunee, Suporn, Niparuck, Pimjai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Università Cattolica del Sacro Cuore 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577552/
https://www.ncbi.nlm.nih.gov/pubmed/34804437
http://dx.doi.org/10.4084/MJHID.2021.063
Descripción
Sumario:BACKGROUND: Double-expressor lymphoma (DEL) was found to account for 20–30% of DLBCL. We conducted this study to analyze the survival, the clinical presentation, and the factors associated with treatment outcomes in DEL-DLBCL. METHODS: A retrospective study of 291 patients diagnosed with DLBCL during January 2015 – December 2018 was conducted. RESULTS: Of the 291 patients, the median age was 63 years, germinal center B cell-like DLBCL (GCB) and non-GCB subtypes were found in 32% and 68%, respectively. DEL was found in 46% of 264 patients with available immunohistochemistry staining for MYC protein. Patients with DEL was significantly more common in elderly patients (p= 0.017) and non-GCB subtype (p= 0.006). High serum lactate dehydrogenase (LDH) levels and high Ki-67 index were significantly found in DEL patients than non-DEL patients (p= 0.024 and p= 0.04, respectively). The 3y-OS rate was shorter in the DEL group than in the non-DEL group, 58.7% versus 78.9% (p=0.026), whereas no significant difference in 3y-DFS was identified between these groups (58.4% versus 67.7%, p= 0.343). Independent factors affecting OS and DFS in DEL patients were ECOG 3–4, high LDH levels, extranodal involvement> 1 site, high IPI, and stage III-IV in univariate analysis. CONCLUSIONS: High incidence of DEL was observed in this study, especially in patients aged 60 years or older and non-GCB subtype. Patients with DEL showed dismal DFS and OS.