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A Validated HPLC-MS/MS Method for Quantification of Methotrexate and Application for Therapeutic Drug Monitoring in Children and Adults with Non-Hodgkin Lymphoma

PURPOSE: A simple, rapid and reliable method to quantify methotrexate (MTX) in human plasma by high-performance liquid chromatography–tandem mass spectrometry (HPLC-MS/MS) was established and validated in two laboratories. PATIENTS AND METHODS: Sample separation was achieved on a Synergi Hydro-RP co...

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Detalles Bibliográficos
Autores principales:	Feng, Zhangying, Gao, Jinglin, Gao, Xiaonan, Hua, Li, Nie, Xuyang, Sun, Yaqi, Wang, Mingxia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577619/ https://www.ncbi.nlm.nih.gov/pubmed/34764639 http://dx.doi.org/10.2147/DDDT.S335122

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