Cargando…
Metagenomic evidence for the co-existence of SARS and H1N1 in patients from 2007-2012 flu seasons in France
By re-analzying public metagenomic data from 101 patients infected with influenza A virus during the 2007-2012 H1N1 flu seasons in France, we identified 22 samples with SARS-CoV sequences. In 3 of them, the SARS genome sequences could be fully assembled out of each. These sequences are highly simila...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier B.V
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577621/ https://www.ncbi.nlm.nih.gov/pubmed/34778742 http://dx.doi.org/10.1016/j.bsheal.2021.11.002 |
_version_ | 1784596097198456832 |
---|---|
author | Liu, Qi Du, Zhenglin Zhu, Sihui Zhao, Wenming Chen, Hua Xue, Yongbiao |
author_facet | Liu, Qi Du, Zhenglin Zhu, Sihui Zhao, Wenming Chen, Hua Xue, Yongbiao |
author_sort | Liu, Qi |
collection | PubMed |
description | By re-analzying public metagenomic data from 101 patients infected with influenza A virus during the 2007-2012 H1N1 flu seasons in France, we identified 22 samples with SARS-CoV sequences. In 3 of them, the SARS genome sequences could be fully assembled out of each. These sequences are highly similar (99.99% and 99.7%) to the artificially constructed recombinant SARS-CoV (SARSr-CoV) strains generated by the J. Craig Venter Institute in the USA. Moreover, samples from different flu seasons have different SARS-CoV strains, and the divergence between these strains cannot be explained by natural evolution. Our study also shows that retrospective studies using public metagenomic data from past major epidemic outbreaks serve as a genomic strategy for researching the origins or spread of infectious diseases. |
format | Online Article Text |
id | pubmed-8577621 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier B.V |
record_format | MEDLINE/PubMed |
spelling | pubmed-85776212021-11-10 Metagenomic evidence for the co-existence of SARS and H1N1 in patients from 2007-2012 flu seasons in France Liu, Qi Du, Zhenglin Zhu, Sihui Zhao, Wenming Chen, Hua Xue, Yongbiao Biosaf Health Article By re-analzying public metagenomic data from 101 patients infected with influenza A virus during the 2007-2012 H1N1 flu seasons in France, we identified 22 samples with SARS-CoV sequences. In 3 of them, the SARS genome sequences could be fully assembled out of each. These sequences are highly similar (99.99% and 99.7%) to the artificially constructed recombinant SARS-CoV (SARSr-CoV) strains generated by the J. Craig Venter Institute in the USA. Moreover, samples from different flu seasons have different SARS-CoV strains, and the divergence between these strains cannot be explained by natural evolution. Our study also shows that retrospective studies using public metagenomic data from past major epidemic outbreaks serve as a genomic strategy for researching the origins or spread of infectious diseases. Elsevier B.V 2021-11-09 /pmc/articles/PMC8577621/ /pubmed/34778742 http://dx.doi.org/10.1016/j.bsheal.2021.11.002 Text en . Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Liu, Qi Du, Zhenglin Zhu, Sihui Zhao, Wenming Chen, Hua Xue, Yongbiao Metagenomic evidence for the co-existence of SARS and H1N1 in patients from 2007-2012 flu seasons in France |
title | Metagenomic evidence for the co-existence of SARS and H1N1 in patients from 2007-2012 flu seasons in France |
title_full | Metagenomic evidence for the co-existence of SARS and H1N1 in patients from 2007-2012 flu seasons in France |
title_fullStr | Metagenomic evidence for the co-existence of SARS and H1N1 in patients from 2007-2012 flu seasons in France |
title_full_unstemmed | Metagenomic evidence for the co-existence of SARS and H1N1 in patients from 2007-2012 flu seasons in France |
title_short | Metagenomic evidence for the co-existence of SARS and H1N1 in patients from 2007-2012 flu seasons in France |
title_sort | metagenomic evidence for the co-existence of sars and h1n1 in patients from 2007-2012 flu seasons in france |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577621/ https://www.ncbi.nlm.nih.gov/pubmed/34778742 http://dx.doi.org/10.1016/j.bsheal.2021.11.002 |
work_keys_str_mv | AT liuqi metagenomicevidenceforthecoexistenceofsarsandh1n1inpatientsfrom20072012fluseasonsinfrance AT duzhenglin metagenomicevidenceforthecoexistenceofsarsandh1n1inpatientsfrom20072012fluseasonsinfrance AT zhusihui metagenomicevidenceforthecoexistenceofsarsandh1n1inpatientsfrom20072012fluseasonsinfrance AT zhaowenming metagenomicevidenceforthecoexistenceofsarsandh1n1inpatientsfrom20072012fluseasonsinfrance AT chenhua metagenomicevidenceforthecoexistenceofsarsandh1n1inpatientsfrom20072012fluseasonsinfrance AT xueyongbiao metagenomicevidenceforthecoexistenceofsarsandh1n1inpatientsfrom20072012fluseasonsinfrance |