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Metagenomic evidence for the co-existence of SARS and H1N1 in patients from 2007-2012 flu seasons in France

By re-analzying public metagenomic data from 101 patients infected with influenza A virus during the 2007-2012 H1N1 flu seasons in France, we identified 22 samples with SARS-CoV sequences. In 3 of them, the SARS genome sequences could be fully assembled out of each. These sequences are highly simila...

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Autores principales: Liu, Qi, Du, Zhenglin, Zhu, Sihui, Zhao, Wenming, Chen, Hua, Xue, Yongbiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577621/
https://www.ncbi.nlm.nih.gov/pubmed/34778742
http://dx.doi.org/10.1016/j.bsheal.2021.11.002
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author Liu, Qi
Du, Zhenglin
Zhu, Sihui
Zhao, Wenming
Chen, Hua
Xue, Yongbiao
author_facet Liu, Qi
Du, Zhenglin
Zhu, Sihui
Zhao, Wenming
Chen, Hua
Xue, Yongbiao
author_sort Liu, Qi
collection PubMed
description By re-analzying public metagenomic data from 101 patients infected with influenza A virus during the 2007-2012 H1N1 flu seasons in France, we identified 22 samples with SARS-CoV sequences. In 3 of them, the SARS genome sequences could be fully assembled out of each. These sequences are highly similar (99.99% and 99.7%) to the artificially constructed recombinant SARS-CoV (SARSr-CoV) strains generated by the J. Craig Venter Institute in the USA. Moreover, samples from different flu seasons have different SARS-CoV strains, and the divergence between these strains cannot be explained by natural evolution. Our study also shows that retrospective studies using public metagenomic data from past major epidemic outbreaks serve as a genomic strategy for researching the origins or spread of infectious diseases.
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spelling pubmed-85776212021-11-10 Metagenomic evidence for the co-existence of SARS and H1N1 in patients from 2007-2012 flu seasons in France Liu, Qi Du, Zhenglin Zhu, Sihui Zhao, Wenming Chen, Hua Xue, Yongbiao Biosaf Health Article By re-analzying public metagenomic data from 101 patients infected with influenza A virus during the 2007-2012 H1N1 flu seasons in France, we identified 22 samples with SARS-CoV sequences. In 3 of them, the SARS genome sequences could be fully assembled out of each. These sequences are highly similar (99.99% and 99.7%) to the artificially constructed recombinant SARS-CoV (SARSr-CoV) strains generated by the J. Craig Venter Institute in the USA. Moreover, samples from different flu seasons have different SARS-CoV strains, and the divergence between these strains cannot be explained by natural evolution. Our study also shows that retrospective studies using public metagenomic data from past major epidemic outbreaks serve as a genomic strategy for researching the origins or spread of infectious diseases. Elsevier B.V 2021-11-09 /pmc/articles/PMC8577621/ /pubmed/34778742 http://dx.doi.org/10.1016/j.bsheal.2021.11.002 Text en . Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Liu, Qi
Du, Zhenglin
Zhu, Sihui
Zhao, Wenming
Chen, Hua
Xue, Yongbiao
Metagenomic evidence for the co-existence of SARS and H1N1 in patients from 2007-2012 flu seasons in France
title Metagenomic evidence for the co-existence of SARS and H1N1 in patients from 2007-2012 flu seasons in France
title_full Metagenomic evidence for the co-existence of SARS and H1N1 in patients from 2007-2012 flu seasons in France
title_fullStr Metagenomic evidence for the co-existence of SARS and H1N1 in patients from 2007-2012 flu seasons in France
title_full_unstemmed Metagenomic evidence for the co-existence of SARS and H1N1 in patients from 2007-2012 flu seasons in France
title_short Metagenomic evidence for the co-existence of SARS and H1N1 in patients from 2007-2012 flu seasons in France
title_sort metagenomic evidence for the co-existence of sars and h1n1 in patients from 2007-2012 flu seasons in france
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577621/
https://www.ncbi.nlm.nih.gov/pubmed/34778742
http://dx.doi.org/10.1016/j.bsheal.2021.11.002
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