Cargando…

Magnetic Resonance-Guided Laser Interstitial Thermal Therapy (MR-gLiTT) in Pediatric Epilepsy Surgery: State of the Art and Presentation of Giannina Gaslini Children's Hospital (Genoa, Italy) Series

Magnetic resonance-guided laser interstitial thermal therapy (MR-gLiTT) is a novel minimally invasive treatment approach for drug-resistant focal epilepsy and brain tumors. Using thermal ablation induced by a laser diode implanted intracranially in a stereotactic manner, the technique is highly effe...

Descripción completa

Detalles Bibliográficos
Autores principales: Consales, Alessandro, Cognolato, Erica, Pacetti, Mattia, Mancardi, Maria Margherita, Tortora, Domenico, Di Perna, Giuseppe, Piatelli, Gianluca, Nobili, Lino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577648/
https://www.ncbi.nlm.nih.gov/pubmed/34764929
http://dx.doi.org/10.3389/fneur.2021.739034
_version_ 1784596103118716928
author Consales, Alessandro
Cognolato, Erica
Pacetti, Mattia
Mancardi, Maria Margherita
Tortora, Domenico
Di Perna, Giuseppe
Piatelli, Gianluca
Nobili, Lino
author_facet Consales, Alessandro
Cognolato, Erica
Pacetti, Mattia
Mancardi, Maria Margherita
Tortora, Domenico
Di Perna, Giuseppe
Piatelli, Gianluca
Nobili, Lino
author_sort Consales, Alessandro
collection PubMed
description Magnetic resonance-guided laser interstitial thermal therapy (MR-gLiTT) is a novel minimally invasive treatment approach for drug-resistant focal epilepsy and brain tumors. Using thermal ablation induced by a laser diode implanted intracranially in a stereotactic manner, the technique is highly effective and safe, reducing the risk associated with more traditional open surgical approaches that could lead to increased neurological morbidity. Indications for MR-gLiTT in pediatric epilepsy surgery include hypothalamic hamartoma, tuberous sclerosis complex, cavernoma-related epilepsy, SEEG-guided seizure onset zone ablation, corpus callosotomy, periventricular nodular heterotopia, mesial temporal lobe epilepsy, and insular epilepsy. We review the available literature on the topic and present our series of patients with drug-resistant epilepsy treated by MR-gLiTT. Our experience, represented by six cases of hypothalamic hamartomas, one case of tuberous sclerosis, and one case of dysembryoplastic neuroepithelial tumor, helps to confirm that MR-gLiTT is a highly safe and effective procedure for several epilepsy conditions in children.
format Online
Article
Text
id pubmed-8577648
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-85776482021-11-10 Magnetic Resonance-Guided Laser Interstitial Thermal Therapy (MR-gLiTT) in Pediatric Epilepsy Surgery: State of the Art and Presentation of Giannina Gaslini Children's Hospital (Genoa, Italy) Series Consales, Alessandro Cognolato, Erica Pacetti, Mattia Mancardi, Maria Margherita Tortora, Domenico Di Perna, Giuseppe Piatelli, Gianluca Nobili, Lino Front Neurol Neurology Magnetic resonance-guided laser interstitial thermal therapy (MR-gLiTT) is a novel minimally invasive treatment approach for drug-resistant focal epilepsy and brain tumors. Using thermal ablation induced by a laser diode implanted intracranially in a stereotactic manner, the technique is highly effective and safe, reducing the risk associated with more traditional open surgical approaches that could lead to increased neurological morbidity. Indications for MR-gLiTT in pediatric epilepsy surgery include hypothalamic hamartoma, tuberous sclerosis complex, cavernoma-related epilepsy, SEEG-guided seizure onset zone ablation, corpus callosotomy, periventricular nodular heterotopia, mesial temporal lobe epilepsy, and insular epilepsy. We review the available literature on the topic and present our series of patients with drug-resistant epilepsy treated by MR-gLiTT. Our experience, represented by six cases of hypothalamic hamartomas, one case of tuberous sclerosis, and one case of dysembryoplastic neuroepithelial tumor, helps to confirm that MR-gLiTT is a highly safe and effective procedure for several epilepsy conditions in children. Frontiers Media S.A. 2021-10-26 /pmc/articles/PMC8577648/ /pubmed/34764929 http://dx.doi.org/10.3389/fneur.2021.739034 Text en Copyright © 2021 Consales, Cognolato, Pacetti, Mancardi, Tortora, Di Perna, Piatelli and Nobili. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Consales, Alessandro
Cognolato, Erica
Pacetti, Mattia
Mancardi, Maria Margherita
Tortora, Domenico
Di Perna, Giuseppe
Piatelli, Gianluca
Nobili, Lino
Magnetic Resonance-Guided Laser Interstitial Thermal Therapy (MR-gLiTT) in Pediatric Epilepsy Surgery: State of the Art and Presentation of Giannina Gaslini Children's Hospital (Genoa, Italy) Series
title Magnetic Resonance-Guided Laser Interstitial Thermal Therapy (MR-gLiTT) in Pediatric Epilepsy Surgery: State of the Art and Presentation of Giannina Gaslini Children's Hospital (Genoa, Italy) Series
title_full Magnetic Resonance-Guided Laser Interstitial Thermal Therapy (MR-gLiTT) in Pediatric Epilepsy Surgery: State of the Art and Presentation of Giannina Gaslini Children's Hospital (Genoa, Italy) Series
title_fullStr Magnetic Resonance-Guided Laser Interstitial Thermal Therapy (MR-gLiTT) in Pediatric Epilepsy Surgery: State of the Art and Presentation of Giannina Gaslini Children's Hospital (Genoa, Italy) Series
title_full_unstemmed Magnetic Resonance-Guided Laser Interstitial Thermal Therapy (MR-gLiTT) in Pediatric Epilepsy Surgery: State of the Art and Presentation of Giannina Gaslini Children's Hospital (Genoa, Italy) Series
title_short Magnetic Resonance-Guided Laser Interstitial Thermal Therapy (MR-gLiTT) in Pediatric Epilepsy Surgery: State of the Art and Presentation of Giannina Gaslini Children's Hospital (Genoa, Italy) Series
title_sort magnetic resonance-guided laser interstitial thermal therapy (mr-glitt) in pediatric epilepsy surgery: state of the art and presentation of giannina gaslini children's hospital (genoa, italy) series
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577648/
https://www.ncbi.nlm.nih.gov/pubmed/34764929
http://dx.doi.org/10.3389/fneur.2021.739034
work_keys_str_mv AT consalesalessandro magneticresonanceguidedlaserinterstitialthermaltherapymrglittinpediatricepilepsysurgerystateoftheartandpresentationofgianninagaslinichildrenshospitalgenoaitalyseries
AT cognolatoerica magneticresonanceguidedlaserinterstitialthermaltherapymrglittinpediatricepilepsysurgerystateoftheartandpresentationofgianninagaslinichildrenshospitalgenoaitalyseries
AT pacettimattia magneticresonanceguidedlaserinterstitialthermaltherapymrglittinpediatricepilepsysurgerystateoftheartandpresentationofgianninagaslinichildrenshospitalgenoaitalyseries
AT mancardimariamargherita magneticresonanceguidedlaserinterstitialthermaltherapymrglittinpediatricepilepsysurgerystateoftheartandpresentationofgianninagaslinichildrenshospitalgenoaitalyseries
AT tortoradomenico magneticresonanceguidedlaserinterstitialthermaltherapymrglittinpediatricepilepsysurgerystateoftheartandpresentationofgianninagaslinichildrenshospitalgenoaitalyseries
AT dipernagiuseppe magneticresonanceguidedlaserinterstitialthermaltherapymrglittinpediatricepilepsysurgerystateoftheartandpresentationofgianninagaslinichildrenshospitalgenoaitalyseries
AT piatelligianluca magneticresonanceguidedlaserinterstitialthermaltherapymrglittinpediatricepilepsysurgerystateoftheartandpresentationofgianninagaslinichildrenshospitalgenoaitalyseries
AT nobililino magneticresonanceguidedlaserinterstitialthermaltherapymrglittinpediatricepilepsysurgerystateoftheartandpresentationofgianninagaslinichildrenshospitalgenoaitalyseries