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Phase I Study of Venetoclax Plus Daratumumab and Dexamethasone, With or Without Bortezomib, in Patients With Relapsed or Refractory Multiple Myeloma With and Without t(11;14)
PURPOSE: Venetoclax is an oral BCL-2 inhibitor with single-agent activity in patients with relapsed or refractory multiple myeloma (RRMM) with t(11;14) translocation. Venetoclax efficacy in RRMM may be potentiated through combination with agents including bortezomib, dexamethasone, and daratumumab....
Autores principales: | Bahlis, Nizar J., Baz, Rachid, Harrison, Simon J., Quach, Hang, Ho, Shir-Jing, Vangsted, Annette Juul, Plesner, Torben, Moreau, Philippe, Gibbs, Simon D., Coppola, Sheryl, Yang, Xiaoqing, Al Masud, Abdullah, Ross, Jeremy A., Bueno, Orlando, Kaufman, Jonathan L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577687/ https://www.ncbi.nlm.nih.gov/pubmed/34388020 http://dx.doi.org/10.1200/JCO.21.00443 |
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