Fixed Drug Eruption Secondary to Four Anti-diabetic Medications: An Unusual Case of Polysensitivity

We report a case of fixed drug eruption in a 58-year-old lady treated for diabetes with four pharmacologically different anti-diabetic agents that were used at separate times of therapy. Skin manifestations, including erythema, blisters, and ulcers, developed over the right leg each time after the i...

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Autores principales: Al Masri, Dana, Fleifel, Mohamad, Hirbli, Kamal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Endocrinology/Diabetes/Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577818/
https://www.ncbi.nlm.nih.gov/pubmed/34786218
http://dx.doi.org/10.7759/cureus.18599
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author Al Masri, Dana
Fleifel, Mohamad
Hirbli, Kamal
author_facet Al Masri, Dana
Fleifel, Mohamad
Hirbli, Kamal
author_sort Al Masri, Dana
collection PubMed
description We report a case of fixed drug eruption in a 58-year-old lady treated for diabetes with four pharmacologically different anti-diabetic agents that were used at separate times of therapy. Skin manifestations, including erythema, blisters, and ulcers, developed over the right leg each time after the initiation of metformin, gliclazide, vildagliptin, and empagliflozin; and disappeared following the discontinuation of the drugs. Magnesium stearate was the common excipient identified in the four agents. This is an extremely rare case of fixed drug eruption caused by structurally dissimilar drugs.
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spelling pubmed-85778182021-11-15 Fixed Drug Eruption Secondary to Four Anti-diabetic Medications: An Unusual Case of Polysensitivity Al Masri, Dana Fleifel, Mohamad Hirbli, Kamal Cureus Endocrinology/Diabetes/Metabolism We report a case of fixed drug eruption in a 58-year-old lady treated for diabetes with four pharmacologically different anti-diabetic agents that were used at separate times of therapy. Skin manifestations, including erythema, blisters, and ulcers, developed over the right leg each time after the initiation of metformin, gliclazide, vildagliptin, and empagliflozin; and disappeared following the discontinuation of the drugs. Magnesium stearate was the common excipient identified in the four agents. This is an extremely rare case of fixed drug eruption caused by structurally dissimilar drugs. Cureus 2021-10-08 /pmc/articles/PMC8577818/ /pubmed/34786218 http://dx.doi.org/10.7759/cureus.18599 Text en Copyright © 2021, Al Masri et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Endocrinology/Diabetes/Metabolism
Al Masri, Dana
Fleifel, Mohamad
Hirbli, Kamal
Fixed Drug Eruption Secondary to Four Anti-diabetic Medications: An Unusual Case of Polysensitivity
title Fixed Drug Eruption Secondary to Four Anti-diabetic Medications: An Unusual Case of Polysensitivity
title_full Fixed Drug Eruption Secondary to Four Anti-diabetic Medications: An Unusual Case of Polysensitivity
title_fullStr Fixed Drug Eruption Secondary to Four Anti-diabetic Medications: An Unusual Case of Polysensitivity
title_full_unstemmed Fixed Drug Eruption Secondary to Four Anti-diabetic Medications: An Unusual Case of Polysensitivity
title_short Fixed Drug Eruption Secondary to Four Anti-diabetic Medications: An Unusual Case of Polysensitivity
title_sort fixed drug eruption secondary to four anti-diabetic medications: an unusual case of polysensitivity
topic Endocrinology/Diabetes/Metabolism
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577818/
https://www.ncbi.nlm.nih.gov/pubmed/34786218
http://dx.doi.org/10.7759/cureus.18599
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AT hirblikamal fixeddrugeruptionsecondarytofourantidiabeticmedicationsanunusualcaseofpolysensitivity

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