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Dynamic cell contacts between periportal mesenchyme and ductal epithelium act as a rheostat for liver cell proliferation
In the liver, ductal cells rarely proliferate during homeostasis but do so transiently after tissue injury. These cells can be expanded as organoids that recapitulate several of the cell-autonomous mechanisms of regeneration but lack the stromal interactions of the native tissue. Here, using organoi...
Autores principales: | Cordero-Espinoza, Lucía, Dowbaj, Anna M., Kohler, Timo N., Strauss, Bernhard, Sarlidou, Olga, Belenguer, German, Pacini, Clare, Martins, Nuno P., Dobie, Ross, Wilson-Kanamori, John R., Butler, Richard, Prior, Nicole, Serup, Palle, Jug, Florian, Henderson, Neil C., Hollfelder, Florian, Huch, Meritxell |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577825/ https://www.ncbi.nlm.nih.gov/pubmed/34343491 http://dx.doi.org/10.1016/j.stem.2021.07.002 |
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