mTORC1-induced retinal progenitor cell overproliferation leads to accelerated mitotic aging and degeneration of descendent Müller glia

Retinal progenitor cells (RPCs) divide in limited numbers to generate the cells comprising vertebrate retina. The molecular mechanism that leads RPC to the division limit, however, remains elusive. Here, we find that the hyperactivation of mechanistic target of rapamycin complex 1 (mTORC1) in an RPC...

Descripción completa

Detalles Bibliográficos
Autores principales: Lim, Soyeon, Kim, You-Joung, Park, Sooyeon, Choi, Ji-heon, Sung, Young Hoon, Nishimori, Katsuhiko, Kozmik, Zbynek, Lee, Han-Woong, Kim, Jin Woo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577849/
https://www.ncbi.nlm.nih.gov/pubmed/34677125
http://dx.doi.org/10.7554/eLife.70079

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577849/
https://www.ncbi.nlm.nih.gov/pubmed/34677125
http://dx.doi.org/10.7554/eLife.70079

Ejemplares similares