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The Hydropathy Index of the HCDR3 Region of the B-Cell Receptor Identifies Two Subgroups of IGHV-Mutated Chronic Lymphocytic Leukemia Patients With Distinct Outcome

The HCDR3 sequences of the B-cell receptor (BCR) undergo constraints in length, amino acid use, and charge during maturation of B-cell precursors and after antigen encounter, leading to BCR and antibodies with high affinity to specific antigens. Chronic lymphocytic leukemia consists of an expansion...

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Detalles Bibliográficos
Autores principales:	Rodríguez-Caballero, Arancha, Fuentes Herrero, Blanca, Oliva Ariza, Guillermo, Criado, Ignacio, Alcoceba, Miguel, Prieto, Carlos, Pérez Caro, María, García-Montero, Andrés C., González Díaz, Marcos, Forconi, Francesco, Sarmento-Ribeiro, Ana Bela, Almeida, Julia, Orfao, Alberto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577851/ https://www.ncbi.nlm.nih.gov/pubmed/34765543 http://dx.doi.org/10.3389/fonc.2021.723722

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