Identification of a therapeutic interfering particle—A single-dose SARS-CoV-2 antiviral intervention with a high barrier to resistance

Viral-deletion mutants that conditionally replicate and inhibit the wild-type virus (i.e., defective interfering particles, DIPs) have long been proposed as single-administration interventions with high genetic barriers to resistance. However, theories predict that robust, therapeutic DIPs (i.e., th...

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Detalles Bibliográficos
Autores principales: Chaturvedi, Sonali, Vasen, Gustavo, Pablo, Michael, Chen, Xinyue, Beutler, Nathan, Kumar, Arjun, Tanner, Elizabeth, Illouz, Sylvia, Rahgoshay, Donna, Burnett, John, Holguin, Leo, Chen, Pei-Yi, Ndjamen, Blaise, Ott, Melanie, Rodick, Robert, Rogers, Thomas, Smith, Davey M., Weinberger, Leor S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577993/
https://www.ncbi.nlm.nih.gov/pubmed/34838159
http://dx.doi.org/10.1016/j.cell.2021.11.004

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