Evaluation and clinical implications of the time to a positive results of antigen testing for SARS-CoV-2

INTRODUCTION: Antigen tests for severe acute respiratory coronavirus 2 sometimes show positive lines earlier than their specified read time, although the implication of getting the results at earlier time is not well understood. METHODS: We prospectively collected additional nasopharyngeal samples f...

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Detalles Bibliográficos
Autores principales: Akashi, Yusaku, Kiyasu, Yoshihiko, Takeuchi, Yuto, Kato, Daisuke, Kuwahara, Miwa, Muramatsu, Shino, Ueda, Atsuo, Notake, Shigeyuki, Nakamura, Koji, Ishikawa, Hiroichi, Suzuki, Hiromichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577995/
https://www.ncbi.nlm.nih.gov/pubmed/34799237
http://dx.doi.org/10.1016/j.jiac.2021.10.026
Descripción
Sumario:INTRODUCTION: Antigen tests for severe acute respiratory coronavirus 2 sometimes show positive lines earlier than their specified read time, although the implication of getting the results at earlier time is not well understood. METHODS: We prospectively collected additional nasopharyngeal samples from patients who had already tested positive for SARS-CoV-2 by reverse transcription PCR. The swab was used for an antigen test, QuickNavi™-COVID19 Ag, and the time periods to get positive results were measured. RESULTS: In 84 of 96 (87.5%) analyzed cases, the results of QuickNavi™-COVID19 Ag were positive. The time to obtain positive results was 15.0 seconds in median (inter quartile range: 12.0–33.3, range 11–736) and was extended in samples with higher cycle thresholds (p < 0.001). Positive lines appeared within a minute in 85.7% of cases and within 5 min in 96.4%. CONCLUSION: QuickNavi™-COVID19 Ag immediately showed positive results in most cases, and the time to a positive reaction may have indicated the viral load.

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