Vaccine-induced thrombosis and thrombocytopenia (VITT) in Ireland: A review of cases and current practices

Since the beginning of the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS CoV-2) virus pandemic, several highly effective and safe vaccines have been produced at remarkable speed. Following global implementation of vaccination programmes, cases of thrombosis with thrombocytopenia following ad...

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Autores principales: Swan, D., Enright, H., Desmond, R., Le, G., El Hassadi, E., Hennessy, B., Lynott, F., O'Keeffe, D., Crowley, M., Smyth, L., Perera, K., Jennings, C., Ni Ainle, F., Coll, J., Ryan, K., O'Donnell, J., Lavin, M., O'Connell, N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8578028/
http://dx.doi.org/10.1016/j.tru.2021.100086
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author Swan, D.
Enright, H.
Desmond, R.
Le, G.
El Hassadi, E.
Hennessy, B.
Lynott, F.
O'Keeffe, D.
Crowley, M.
Smyth, L.
Perera, K.
Jennings, C.
Ni Ainle, F.
Coll, J.
Ryan, K.
O'Donnell, J.
Lavin, M.
O'Connell, N.
author_facet Swan, D.
Enright, H.
Desmond, R.
Le, G.
El Hassadi, E.
Hennessy, B.
Lynott, F.
O'Keeffe, D.
Crowley, M.
Smyth, L.
Perera, K.
Jennings, C.
Ni Ainle, F.
Coll, J.
Ryan, K.
O'Donnell, J.
Lavin, M.
O'Connell, N.
author_sort Swan, D.
collection PubMed
description Since the beginning of the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS CoV-2) virus pandemic, several highly effective and safe vaccines have been produced at remarkable speed. Following global implementation of vaccination programmes, cases of thrombosis with thrombocytopenia following administration of adenoviral vector-based vaccines started being reported. In this review we discuss the known pathogenesis and epidemiology of so-called vaccine induced thrombocytopenia and thrombosis (VITT). We consider the available guidelines, diagnostic laboratory tests and management options for these patients. Finally, we discuss important unanswered questions and areas for future research in this novel pathoclinical entity.
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spelling pubmed-85780282021-11-10 Vaccine-induced thrombosis and thrombocytopenia (VITT) in Ireland: A review of cases and current practices Swan, D. Enright, H. Desmond, R. Le, G. El Hassadi, E. Hennessy, B. Lynott, F. O'Keeffe, D. Crowley, M. Smyth, L. Perera, K. Jennings, C. Ni Ainle, F. Coll, J. Ryan, K. O'Donnell, J. Lavin, M. O'Connell, N. Thrombosis Update Article Since the beginning of the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS CoV-2) virus pandemic, several highly effective and safe vaccines have been produced at remarkable speed. Following global implementation of vaccination programmes, cases of thrombosis with thrombocytopenia following administration of adenoviral vector-based vaccines started being reported. In this review we discuss the known pathogenesis and epidemiology of so-called vaccine induced thrombocytopenia and thrombosis (VITT). We consider the available guidelines, diagnostic laboratory tests and management options for these patients. Finally, we discuss important unanswered questions and areas for future research in this novel pathoclinical entity. Published by Elsevier Ltd. 2021-12 2021-11-10 /pmc/articles/PMC8578028/ http://dx.doi.org/10.1016/j.tru.2021.100086 Text en © 2021 Published by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Swan, D.
Enright, H.
Desmond, R.
Le, G.
El Hassadi, E.
Hennessy, B.
Lynott, F.
O'Keeffe, D.
Crowley, M.
Smyth, L.
Perera, K.
Jennings, C.
Ni Ainle, F.
Coll, J.
Ryan, K.
O'Donnell, J.
Lavin, M.
O'Connell, N.
Vaccine-induced thrombosis and thrombocytopenia (VITT) in Ireland: A review of cases and current practices
title Vaccine-induced thrombosis and thrombocytopenia (VITT) in Ireland: A review of cases and current practices
title_full Vaccine-induced thrombosis and thrombocytopenia (VITT) in Ireland: A review of cases and current practices
title_fullStr Vaccine-induced thrombosis and thrombocytopenia (VITT) in Ireland: A review of cases and current practices
title_full_unstemmed Vaccine-induced thrombosis and thrombocytopenia (VITT) in Ireland: A review of cases and current practices
title_short Vaccine-induced thrombosis and thrombocytopenia (VITT) in Ireland: A review of cases and current practices
title_sort vaccine-induced thrombosis and thrombocytopenia (vitt) in ireland: a review of cases and current practices
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8578028/
http://dx.doi.org/10.1016/j.tru.2021.100086
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