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Novel Anti-inflammatory Effects of Canagliflozin Involving Hexokinase II in Lipopolysaccharide-Stimulated Human Coronary Artery Endothelial Cells

PURPOSE: Vascular inflammation and disturbed metabolism are observed in heart failure and type 2 diabetes mellitus. Glycolytic enzyme hexokinase II (HKII) is upregulated by inflammation. We hypothesized that SGLT2 inhibitors Canagliflozin (Cana), Empagliflozin (Empa) or Dapagliflozin (Dapa) reduces...

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Detalles Bibliográficos
Autores principales:	Uthman, Laween, Kuschma, Marius, Römer, Gregor, Boomsma, Marleen, Kessler, Jens, Hermanides, Jeroen, Hollmann, Markus W., Preckel, Benedikt, Zuurbier, Coert J., Weber, Nina C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8578058/ https://www.ncbi.nlm.nih.gov/pubmed/33048256 http://dx.doi.org/10.1007/s10557-020-07083-w

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