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Peak ependymal cell stretch overlaps with the onset locations of periventricular white matter lesions

Deep and periventricular white matter hyperintensities (dWMH/pvWMH) are bright appearing white matter tissue lesions in T2-weighted fluid attenuated inversion recovery magnetic resonance images and are frequent observations in the aging human brain. While early stages of these white matter lesions a...

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Autores principales: Visser, Valery L., Rusinek, Henry, Weickenmeier, Johannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8578319/
https://www.ncbi.nlm.nih.gov/pubmed/34753951
http://dx.doi.org/10.1038/s41598-021-00610-1
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author Visser, Valery L.
Rusinek, Henry
Weickenmeier, Johannes
author_facet Visser, Valery L.
Rusinek, Henry
Weickenmeier, Johannes
author_sort Visser, Valery L.
collection PubMed
description Deep and periventricular white matter hyperintensities (dWMH/pvWMH) are bright appearing white matter tissue lesions in T2-weighted fluid attenuated inversion recovery magnetic resonance images and are frequent observations in the aging human brain. While early stages of these white matter lesions are only weakly associated with cognitive impairment, their progressive growth is a strong indicator for long-term functional decline. DWMHs are typically associated with vascular degeneration in diffuse white matter locations; for pvWMHs, however, no unifying theory exists to explain their consistent onset around the horns of the lateral ventricles. We use patient imaging data to create anatomically accurate finite element models of the lateral ventricles, white and gray matter, and cerebrospinal fluid, as well as to reconstruct their WMH volumes. We simulated the mechanical loading of the ependymal cells forming the primary brain-fluid interface, the ventricular wall, and its surrounding tissues at peak ventricular pressure during the hemodynamic cycle. We observe that both the maximum principal tissue strain and the largest ependymal cell stretch consistently localize in the anterior and posterior horns. Our simulations show that ependymal cells experience a loading state that causes the ventricular wall to be stretched thin. Moreover, we show that maximum wall loading coincides with the pvWMH locations observed in our patient scans. These results warrant further analysis of white matter pathology in the periventricular zone that includes a mechanics-driven deterioration model for the ventricular wall.
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spelling pubmed-85783192021-11-10 Peak ependymal cell stretch overlaps with the onset locations of periventricular white matter lesions Visser, Valery L. Rusinek, Henry Weickenmeier, Johannes Sci Rep Article Deep and periventricular white matter hyperintensities (dWMH/pvWMH) are bright appearing white matter tissue lesions in T2-weighted fluid attenuated inversion recovery magnetic resonance images and are frequent observations in the aging human brain. While early stages of these white matter lesions are only weakly associated with cognitive impairment, their progressive growth is a strong indicator for long-term functional decline. DWMHs are typically associated with vascular degeneration in diffuse white matter locations; for pvWMHs, however, no unifying theory exists to explain their consistent onset around the horns of the lateral ventricles. We use patient imaging data to create anatomically accurate finite element models of the lateral ventricles, white and gray matter, and cerebrospinal fluid, as well as to reconstruct their WMH volumes. We simulated the mechanical loading of the ependymal cells forming the primary brain-fluid interface, the ventricular wall, and its surrounding tissues at peak ventricular pressure during the hemodynamic cycle. We observe that both the maximum principal tissue strain and the largest ependymal cell stretch consistently localize in the anterior and posterior horns. Our simulations show that ependymal cells experience a loading state that causes the ventricular wall to be stretched thin. Moreover, we show that maximum wall loading coincides with the pvWMH locations observed in our patient scans. These results warrant further analysis of white matter pathology in the periventricular zone that includes a mechanics-driven deterioration model for the ventricular wall. Nature Publishing Group UK 2021-11-09 /pmc/articles/PMC8578319/ /pubmed/34753951 http://dx.doi.org/10.1038/s41598-021-00610-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Visser, Valery L.
Rusinek, Henry
Weickenmeier, Johannes
Peak ependymal cell stretch overlaps with the onset locations of periventricular white matter lesions
title Peak ependymal cell stretch overlaps with the onset locations of periventricular white matter lesions
title_full Peak ependymal cell stretch overlaps with the onset locations of periventricular white matter lesions
title_fullStr Peak ependymal cell stretch overlaps with the onset locations of periventricular white matter lesions
title_full_unstemmed Peak ependymal cell stretch overlaps with the onset locations of periventricular white matter lesions
title_short Peak ependymal cell stretch overlaps with the onset locations of periventricular white matter lesions
title_sort peak ependymal cell stretch overlaps with the onset locations of periventricular white matter lesions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8578319/
https://www.ncbi.nlm.nih.gov/pubmed/34753951
http://dx.doi.org/10.1038/s41598-021-00610-1
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