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Risk factors for subjective cognitive decline: the CABLE study

Increasing evidences supported that subjective cognitive decline (SCD) might be a potential first symptomatic manifestation of Alzheimer’s disease (AD). The rapidly growing number of SCD individuals who seek medical help and advice also makes it urgent to develop more precise strategy for SCD. There...

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Autores principales: Wen, Chen, Hu, Hao, Ou, Ya-Nan, Bi, Yan-Lin, Ma, Ya-Hui, Tan, Lan, Yu, Jin-Tai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8578345/
https://www.ncbi.nlm.nih.gov/pubmed/34753917
http://dx.doi.org/10.1038/s41398-021-01711-1
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author Wen, Chen
Hu, Hao
Ou, Ya-Nan
Bi, Yan-Lin
Ma, Ya-Hui
Tan, Lan
Yu, Jin-Tai
author_facet Wen, Chen
Hu, Hao
Ou, Ya-Nan
Bi, Yan-Lin
Ma, Ya-Hui
Tan, Lan
Yu, Jin-Tai
author_sort Wen, Chen
collection PubMed
description Increasing evidences supported that subjective cognitive decline (SCD) might be a potential first symptomatic manifestation of Alzheimer’s disease (AD). The rapidly growing number of SCD individuals who seek medical help and advice also makes it urgent to develop more precise strategy for SCD. Therefore, this study aimed to explore the risk factors for SCD. Logistics and linear regression models were performed to investigate 41 factors for SCD in 1165 participants without objective cognitive impairment. Cochran-Armitage trend test was used to confirm the constant trend toward higher prevalence of SCD with an increasing number of risk factors. A high overall prevalence of SCD was found in total participants (42%). Eight factors were eventually identified as risk factors for SCD, including four stable factors associated with both SCD statues and severity (older age, thyroid diseases, minimal anxiety symptoms, and day time dysfunction; odds ratio (OR) ranging from 1.74 to 2.29) as well as four suggestive factors associated with either SCD statues or severity (female sex, anemia, lack of physical exercises, and living alone; OR ranging from 1.30 to 2.29). The prevalence of SCD gradually increased with the number of risk factors clustering increased in individuals (p for trend <0.001). Five of these eight factors were further proved among individuals with SCD-plus features. These findings revealed several risk factors for SCD, providing some new clues for formulating priority strategies for early prevention of SCD.
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spelling pubmed-85783452021-11-15 Risk factors for subjective cognitive decline: the CABLE study Wen, Chen Hu, Hao Ou, Ya-Nan Bi, Yan-Lin Ma, Ya-Hui Tan, Lan Yu, Jin-Tai Transl Psychiatry Article Increasing evidences supported that subjective cognitive decline (SCD) might be a potential first symptomatic manifestation of Alzheimer’s disease (AD). The rapidly growing number of SCD individuals who seek medical help and advice also makes it urgent to develop more precise strategy for SCD. Therefore, this study aimed to explore the risk factors for SCD. Logistics and linear regression models were performed to investigate 41 factors for SCD in 1165 participants without objective cognitive impairment. Cochran-Armitage trend test was used to confirm the constant trend toward higher prevalence of SCD with an increasing number of risk factors. A high overall prevalence of SCD was found in total participants (42%). Eight factors were eventually identified as risk factors for SCD, including four stable factors associated with both SCD statues and severity (older age, thyroid diseases, minimal anxiety symptoms, and day time dysfunction; odds ratio (OR) ranging from 1.74 to 2.29) as well as four suggestive factors associated with either SCD statues or severity (female sex, anemia, lack of physical exercises, and living alone; OR ranging from 1.30 to 2.29). The prevalence of SCD gradually increased with the number of risk factors clustering increased in individuals (p for trend <0.001). Five of these eight factors were further proved among individuals with SCD-plus features. These findings revealed several risk factors for SCD, providing some new clues for formulating priority strategies for early prevention of SCD. Nature Publishing Group UK 2021-11-09 /pmc/articles/PMC8578345/ /pubmed/34753917 http://dx.doi.org/10.1038/s41398-021-01711-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Wen, Chen
Hu, Hao
Ou, Ya-Nan
Bi, Yan-Lin
Ma, Ya-Hui
Tan, Lan
Yu, Jin-Tai
Risk factors for subjective cognitive decline: the CABLE study
title Risk factors for subjective cognitive decline: the CABLE study
title_full Risk factors for subjective cognitive decline: the CABLE study
title_fullStr Risk factors for subjective cognitive decline: the CABLE study
title_full_unstemmed Risk factors for subjective cognitive decline: the CABLE study
title_short Risk factors for subjective cognitive decline: the CABLE study
title_sort risk factors for subjective cognitive decline: the cable study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8578345/
https://www.ncbi.nlm.nih.gov/pubmed/34753917
http://dx.doi.org/10.1038/s41398-021-01711-1
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