Genetic inhibition of RIPK3 ameliorates functional outcome in controlled cortical impact independent of necroptosis

Traumatic brain injury (TBI) is a leading cause of death and disability with no specific effective therapy, in part because disease driving mechanisms remain to be elucidated. Receptor interacting protein kinases (RIPKs) are serine/threonine kinases that assemble multi-molecular complexes that induc...

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Detalles Bibliográficos
Autores principales: Wu, Limin, Chung, Joon Yong, Cao, Tian, Jin, Gina, Edmiston, William J., Hickman, Suzanne, Levy, Emily S., Whalen, Jordyn A., Abrams, Eliza Sophie LaRovere, Degterev, Alexei, Lo, Eng H., Tozzi, Lorenzo, Kaplan, David L., El Khoury, Joseph, Whalen, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8578385/
https://www.ncbi.nlm.nih.gov/pubmed/34753914
http://dx.doi.org/10.1038/s41419-021-04333-z

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