Phosphorylation-dependent BRD4 dimerization and implications for therapeutic inhibition of BET family proteins

Bromodomain-containing protein 4 (BRD4) is an epigenetic reader and oncology drug target that regulates gene transcription through binding to acetylated chromatin via bromodomains. Phosphorylation by casein kinase II (CK2) regulates BRD4 function, is necessary for active transcription and is involve...

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Detalles Bibliográficos
Autores principales: Malvezzi, Francesca, Stubbs, Christopher J., Jowitt, Thomas A., Dale, Ian L., Guo, Xieyang, DeGnore, Jon P., Degliesposti, Gianluca, Skehel, J. Mark, Bannister, Andrew J., McAlister, Mark S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8578508/
https://www.ncbi.nlm.nih.gov/pubmed/34754068
http://dx.doi.org/10.1038/s42003-021-02750-6

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