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Dictyostelium discoideum as a Model for Investigating Neurodegenerative Diseases
The social amoeba Dictyostelium discoideum is a model organism that is used to investigate many cellular processes including chemotaxis, cell motility, cell differentiation, and human disease pathogenesis. While many single-cellular model systems lack homologs of human disease genes, Dictyostelium’s...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8578527/ https://www.ncbi.nlm.nih.gov/pubmed/34776869 http://dx.doi.org/10.3389/fncel.2021.759532 |
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author | Haver, Holly N. Scaglione, K. Matthew |
author_facet | Haver, Holly N. Scaglione, K. Matthew |
author_sort | Haver, Holly N. |
collection | PubMed |
description | The social amoeba Dictyostelium discoideum is a model organism that is used to investigate many cellular processes including chemotaxis, cell motility, cell differentiation, and human disease pathogenesis. While many single-cellular model systems lack homologs of human disease genes, Dictyostelium’s genome encodes for many genes that are implicated in human diseases including neurodegenerative diseases. Due to its short doubling time along with the powerful genetic tools that enable rapid genetic screening, and the ease of creating knockout cell lines, Dictyostelium is an attractive model organism for both interrogating the normal function of genes implicated in neurodegeneration and for determining pathogenic mechanisms that cause disease. Here we review the literature involving the use of Dictyostelium to interrogate genes implicated in neurodegeneration and highlight key questions that can be addressed using Dictyostelium as a model organism. |
format | Online Article Text |
id | pubmed-8578527 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85785272021-11-11 Dictyostelium discoideum as a Model for Investigating Neurodegenerative Diseases Haver, Holly N. Scaglione, K. Matthew Front Cell Neurosci Cellular Neuroscience The social amoeba Dictyostelium discoideum is a model organism that is used to investigate many cellular processes including chemotaxis, cell motility, cell differentiation, and human disease pathogenesis. While many single-cellular model systems lack homologs of human disease genes, Dictyostelium’s genome encodes for many genes that are implicated in human diseases including neurodegenerative diseases. Due to its short doubling time along with the powerful genetic tools that enable rapid genetic screening, and the ease of creating knockout cell lines, Dictyostelium is an attractive model organism for both interrogating the normal function of genes implicated in neurodegeneration and for determining pathogenic mechanisms that cause disease. Here we review the literature involving the use of Dictyostelium to interrogate genes implicated in neurodegeneration and highlight key questions that can be addressed using Dictyostelium as a model organism. Frontiers Media S.A. 2021-10-27 /pmc/articles/PMC8578527/ /pubmed/34776869 http://dx.doi.org/10.3389/fncel.2021.759532 Text en Copyright © 2021 Haver and Scaglione. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cellular Neuroscience Haver, Holly N. Scaglione, K. Matthew Dictyostelium discoideum as a Model for Investigating Neurodegenerative Diseases |
title | Dictyostelium discoideum as a Model for Investigating Neurodegenerative Diseases |
title_full | Dictyostelium discoideum as a Model for Investigating Neurodegenerative Diseases |
title_fullStr | Dictyostelium discoideum as a Model for Investigating Neurodegenerative Diseases |
title_full_unstemmed | Dictyostelium discoideum as a Model for Investigating Neurodegenerative Diseases |
title_short | Dictyostelium discoideum as a Model for Investigating Neurodegenerative Diseases |
title_sort | dictyostelium discoideum as a model for investigating neurodegenerative diseases |
topic | Cellular Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8578527/ https://www.ncbi.nlm.nih.gov/pubmed/34776869 http://dx.doi.org/10.3389/fncel.2021.759532 |
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