Tunable control of CAR T cell activity through tetracycline mediated disruption of protein–protein interaction

Chimeric antigen receptor (CAR) T cells are a promising form of cancer immunotherapy, although they are often associated with severe toxicities. Here, we present a split-CAR design incorporating separate antigen recognition and intracellular signaling domains. These exploit the binding between the t...

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Detalles Bibliográficos
Autores principales: Hotblack, Alastair, Kokalaki, Evangelia K., Palton, Morgan J., Cheung, Gordon Weng-Kit, Williams, Iwan P., Manzoor, Somayya, Grothier, Thomas I., Piapi, Alice, Fiaccadori, Valeria, Wawrzyniecka, Patrycja, Roddy, Harriet A., Agliardi, Giulia, Roddie, Claire, Onuoha, Shimobi, Thomas, Simon, Cordoba, Shaun, Pule, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8578617/
https://www.ncbi.nlm.nih.gov/pubmed/34754016
http://dx.doi.org/10.1038/s41598-021-01418-9

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