Inability to switch from ARID1A-BAF to ARID1B-BAF impairs exit from pluripotency and commitment towards neural crest formation in ARID1B-related neurodevelopmental disorders

Subunit switches in the BAF chromatin remodeler are essential during development. ARID1B and its paralog ARID1A encode for mutually exclusive BAF subunits. De novo ARID1B haploinsufficient mutations cause neurodevelopmental disorders, including Coffin-Siris syndrome, which is characterized by neurol...

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Detalles Bibliográficos
Autores principales: Pagliaroli, Luca, Porazzi, Patrizia, Curtis, Alyxandra T., Scopa, Chiara, Mikkers, Harald M. M., Freund, Christian, Daxinger, Lucia, Deliard, Sandra, Welsh, Sarah A., Offley, Sarah, Ott, Connor A., Calabretta, Bruno, Brugmann, Samantha A., Santen, Gijs W. E., Trizzino, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8578637/
https://www.ncbi.nlm.nih.gov/pubmed/34753942
http://dx.doi.org/10.1038/s41467-021-26810-x

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