rRNA biogenesis regulates mouse 2C-like state by 3D structure reorganization of peri-nucleolar heterochromatin

The nucleolus is the organelle for ribosome biogenesis and sensing various types of stress. However, its role in regulating stem cell fate remains unclear. Here, we present evidence that nucleolar stress induced by interfering rRNA biogenesis can drive the 2-cell stage embryo-like (2C-like) program...

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Detalles Bibliográficos
Autores principales: Yu, Hua, Sun, Zhen, Tan, Tianyu, Pan, Hongru, Zhao, Jing, Zhang, Ling, Chen, Jiayu, Lei, Anhua, Zhu, Yuqing, Chen, Lang, Xu, Yuyan, Liu, Yaxin, Chen, Ming, Sheng, Jinghao, Xu, Zhengping, Qian, Pengxu, Li, Cheng, Gao, Shaorong, Daley, George Q., Zhang, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8578659/
https://www.ncbi.nlm.nih.gov/pubmed/34753899
http://dx.doi.org/10.1038/s41467-021-26576-2

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