Roles and mechanisms of exosomal non-coding RNAs in human health and diseases

Exosomes play a role as mediators of cell-to-cell communication, thus exhibiting pleiotropic activities to homeostasis regulation. Exosomal non-coding RNAs (ncRNAs), mainly microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), are closely related to a variety of biologica...

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Autores principales: Li, Chen, Ni, Yu-Qing, Xu, Hui, Xiang, Qun-Yan, Zhao, Yan, Zhan, Jun-Kun, He, Jie-Yu, Li, Shuang, Liu, You-Shuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8578673/
https://www.ncbi.nlm.nih.gov/pubmed/34753929
http://dx.doi.org/10.1038/s41392-021-00779-x
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author Li, Chen
Ni, Yu-Qing
Xu, Hui
Xiang, Qun-Yan
Zhao, Yan
Zhan, Jun-Kun
He, Jie-Yu
Li, Shuang
Liu, You-Shuo
author_facet Li, Chen
Ni, Yu-Qing
Xu, Hui
Xiang, Qun-Yan
Zhao, Yan
Zhan, Jun-Kun
He, Jie-Yu
Li, Shuang
Liu, You-Shuo
author_sort Li, Chen
collection PubMed
description Exosomes play a role as mediators of cell-to-cell communication, thus exhibiting pleiotropic activities to homeostasis regulation. Exosomal non-coding RNAs (ncRNAs), mainly microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), are closely related to a variety of biological and functional aspects of human health. When the exosomal ncRNAs undergo tissue-specific changes due to diverse internal or external disorders, they can cause tissue dysfunction, aging, and diseases. In this review, we comprehensively discuss the underlying regulatory mechanisms of exosomes in human diseases. In addition, we explore the current knowledge on the roles of exosomal miRNAs, lncRNAs, and circRNAs in human health and diseases, including cancers, metabolic diseases, neurodegenerative diseases, cardiovascular diseases, autoimmune diseases, and infectious diseases, to determine their potential implication in biomarker identification and therapeutic exploration.
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spelling pubmed-85786732021-11-15 Roles and mechanisms of exosomal non-coding RNAs in human health and diseases Li, Chen Ni, Yu-Qing Xu, Hui Xiang, Qun-Yan Zhao, Yan Zhan, Jun-Kun He, Jie-Yu Li, Shuang Liu, You-Shuo Signal Transduct Target Ther Review Article Exosomes play a role as mediators of cell-to-cell communication, thus exhibiting pleiotropic activities to homeostasis regulation. Exosomal non-coding RNAs (ncRNAs), mainly microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), are closely related to a variety of biological and functional aspects of human health. When the exosomal ncRNAs undergo tissue-specific changes due to diverse internal or external disorders, they can cause tissue dysfunction, aging, and diseases. In this review, we comprehensively discuss the underlying regulatory mechanisms of exosomes in human diseases. In addition, we explore the current knowledge on the roles of exosomal miRNAs, lncRNAs, and circRNAs in human health and diseases, including cancers, metabolic diseases, neurodegenerative diseases, cardiovascular diseases, autoimmune diseases, and infectious diseases, to determine their potential implication in biomarker identification and therapeutic exploration. Nature Publishing Group UK 2021-11-10 /pmc/articles/PMC8578673/ /pubmed/34753929 http://dx.doi.org/10.1038/s41392-021-00779-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Li, Chen
Ni, Yu-Qing
Xu, Hui
Xiang, Qun-Yan
Zhao, Yan
Zhan, Jun-Kun
He, Jie-Yu
Li, Shuang
Liu, You-Shuo
Roles and mechanisms of exosomal non-coding RNAs in human health and diseases
title Roles and mechanisms of exosomal non-coding RNAs in human health and diseases
title_full Roles and mechanisms of exosomal non-coding RNAs in human health and diseases
title_fullStr Roles and mechanisms of exosomal non-coding RNAs in human health and diseases
title_full_unstemmed Roles and mechanisms of exosomal non-coding RNAs in human health and diseases
title_short Roles and mechanisms of exosomal non-coding RNAs in human health and diseases
title_sort roles and mechanisms of exosomal non-coding rnas in human health and diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8578673/
https://www.ncbi.nlm.nih.gov/pubmed/34753929
http://dx.doi.org/10.1038/s41392-021-00779-x
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