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Tumor Microenvironment–Responsive Polypeptide Nanogels for Controlled Antitumor Drug Delivery

Tumor microenvironment–responsive polypeptide nanogels belong to a biomaterial with excellent biocompatibility, easily adjustable performance, biodegradability, and non-toxic properties. They are developed for selective delivery of antitumor drugs into target organs to promote tumor cell uptake, whi...

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Detalles Bibliográficos
Autores principales: Liu, Yanhong, Chen, Linjiao, Shi, Qingyang, Zhao, Qing, Ma, Hongshuang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8578677/
https://www.ncbi.nlm.nih.gov/pubmed/34776965
http://dx.doi.org/10.3389/fphar.2021.748102
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author Liu, Yanhong
Chen, Linjiao
Shi, Qingyang
Zhao, Qing
Ma, Hongshuang
author_facet Liu, Yanhong
Chen, Linjiao
Shi, Qingyang
Zhao, Qing
Ma, Hongshuang
author_sort Liu, Yanhong
collection PubMed
description Tumor microenvironment–responsive polypeptide nanogels belong to a biomaterial with excellent biocompatibility, easily adjustable performance, biodegradability, and non-toxic properties. They are developed for selective delivery of antitumor drugs into target organs to promote tumor cell uptake, which has become an effective measure of tumor treatment. Endogenous (such as reduction, reactive oxygen species, pH, and enzyme) and exogenous (such as light and temperature) responsive nanogels can release drugs in response to tumor tissues or cells to improve drug distribution and reduce drug side effects. This article systematically introduces the research progress in tumor microenvironment–responsive polypeptide nanogels to deliver antitumor drugs and provides a reference for the development of antitumor nanoformulations.
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spelling pubmed-85786772021-11-11 Tumor Microenvironment–Responsive Polypeptide Nanogels for Controlled Antitumor Drug Delivery Liu, Yanhong Chen, Linjiao Shi, Qingyang Zhao, Qing Ma, Hongshuang Front Pharmacol Pharmacology Tumor microenvironment–responsive polypeptide nanogels belong to a biomaterial with excellent biocompatibility, easily adjustable performance, biodegradability, and non-toxic properties. They are developed for selective delivery of antitumor drugs into target organs to promote tumor cell uptake, which has become an effective measure of tumor treatment. Endogenous (such as reduction, reactive oxygen species, pH, and enzyme) and exogenous (such as light and temperature) responsive nanogels can release drugs in response to tumor tissues or cells to improve drug distribution and reduce drug side effects. This article systematically introduces the research progress in tumor microenvironment–responsive polypeptide nanogels to deliver antitumor drugs and provides a reference for the development of antitumor nanoformulations. Frontiers Media S.A. 2021-10-27 /pmc/articles/PMC8578677/ /pubmed/34776965 http://dx.doi.org/10.3389/fphar.2021.748102 Text en Copyright © 2021 Liu, Chen, Shi, Zhao and Ma. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Liu, Yanhong
Chen, Linjiao
Shi, Qingyang
Zhao, Qing
Ma, Hongshuang
Tumor Microenvironment–Responsive Polypeptide Nanogels for Controlled Antitumor Drug Delivery
title Tumor Microenvironment–Responsive Polypeptide Nanogels for Controlled Antitumor Drug Delivery
title_full Tumor Microenvironment–Responsive Polypeptide Nanogels for Controlled Antitumor Drug Delivery
title_fullStr Tumor Microenvironment–Responsive Polypeptide Nanogels for Controlled Antitumor Drug Delivery
title_full_unstemmed Tumor Microenvironment–Responsive Polypeptide Nanogels for Controlled Antitumor Drug Delivery
title_short Tumor Microenvironment–Responsive Polypeptide Nanogels for Controlled Antitumor Drug Delivery
title_sort tumor microenvironment–responsive polypeptide nanogels for controlled antitumor drug delivery
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8578677/
https://www.ncbi.nlm.nih.gov/pubmed/34776965
http://dx.doi.org/10.3389/fphar.2021.748102
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