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Mathematical Modelling of COVID-19 Transmission in Kenya: A Model with Reinfection Transmission Mechanism
In this study we propose a Coronavirus Disease 2019 (COVID-19) mathematical model that stratifies infectious subpopulations into: infectious asymptomatic individuals, symptomatic infectious individuals who manifest mild symptoms and symptomatic individuals with severe symptoms. In light of the recen...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8578696/ https://www.ncbi.nlm.nih.gov/pubmed/34777563 http://dx.doi.org/10.1155/2021/5384481 |
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author | Wangari, Isaac Mwangi Sewe, Stanley Kimathi, George Wainaina, Mary Kitetu, Virginia Kaluki, Winnie |
author_facet | Wangari, Isaac Mwangi Sewe, Stanley Kimathi, George Wainaina, Mary Kitetu, Virginia Kaluki, Winnie |
author_sort | Wangari, Isaac Mwangi |
collection | PubMed |
description | In this study we propose a Coronavirus Disease 2019 (COVID-19) mathematical model that stratifies infectious subpopulations into: infectious asymptomatic individuals, symptomatic infectious individuals who manifest mild symptoms and symptomatic individuals with severe symptoms. In light of the recent revelation that reinfection by COVID-19 is possible, the proposed model attempt to investigate how reinfection with COVID-19 will alter the future dynamics of the recent unfolding pandemic. Fitting the mathematical model on the Kenya COVID-19 dataset, model parameter values were obtained and used to conduct numerical simulations. Numerical results suggest that reinfection of recovered individuals who have lost their protective immunity will create a large pool of asymptomatic infectious individuals which will ultimately increase symptomatic individuals with mild symptoms and symptomatic individuals with severe symptoms (critically ill) needing urgent medical attention. The model suggests that reinfection with COVID-19 will lead to an increase in cumulative reported deaths. Comparison of the impact of non pharmaceutical interventions on curbing COVID19 proliferation suggests that wearing face masks profoundly reduce COVID-19 prevalence than maintaining social/physical distance. Further, numerical findings reveal that increasing detection rate of asymptomatic cases via contact tracing, testing and isolating them can drastically reduce COVID-19 surge, in particular individuals who are critically ill and require admission into intensive care. |
format | Online Article Text |
id | pubmed-8578696 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-85786962021-11-11 Mathematical Modelling of COVID-19 Transmission in Kenya: A Model with Reinfection Transmission Mechanism Wangari, Isaac Mwangi Sewe, Stanley Kimathi, George Wainaina, Mary Kitetu, Virginia Kaluki, Winnie Comput Math Methods Med Research Article In this study we propose a Coronavirus Disease 2019 (COVID-19) mathematical model that stratifies infectious subpopulations into: infectious asymptomatic individuals, symptomatic infectious individuals who manifest mild symptoms and symptomatic individuals with severe symptoms. In light of the recent revelation that reinfection by COVID-19 is possible, the proposed model attempt to investigate how reinfection with COVID-19 will alter the future dynamics of the recent unfolding pandemic. Fitting the mathematical model on the Kenya COVID-19 dataset, model parameter values were obtained and used to conduct numerical simulations. Numerical results suggest that reinfection of recovered individuals who have lost their protective immunity will create a large pool of asymptomatic infectious individuals which will ultimately increase symptomatic individuals with mild symptoms and symptomatic individuals with severe symptoms (critically ill) needing urgent medical attention. The model suggests that reinfection with COVID-19 will lead to an increase in cumulative reported deaths. Comparison of the impact of non pharmaceutical interventions on curbing COVID19 proliferation suggests that wearing face masks profoundly reduce COVID-19 prevalence than maintaining social/physical distance. Further, numerical findings reveal that increasing detection rate of asymptomatic cases via contact tracing, testing and isolating them can drastically reduce COVID-19 surge, in particular individuals who are critically ill and require admission into intensive care. Hindawi 2021-10-16 /pmc/articles/PMC8578696/ /pubmed/34777563 http://dx.doi.org/10.1155/2021/5384481 Text en Copyright © 2021 Isaac Mwangi Wangari et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Wangari, Isaac Mwangi Sewe, Stanley Kimathi, George Wainaina, Mary Kitetu, Virginia Kaluki, Winnie Mathematical Modelling of COVID-19 Transmission in Kenya: A Model with Reinfection Transmission Mechanism |
title | Mathematical Modelling of COVID-19 Transmission in Kenya: A Model with Reinfection Transmission Mechanism |
title_full | Mathematical Modelling of COVID-19 Transmission in Kenya: A Model with Reinfection Transmission Mechanism |
title_fullStr | Mathematical Modelling of COVID-19 Transmission in Kenya: A Model with Reinfection Transmission Mechanism |
title_full_unstemmed | Mathematical Modelling of COVID-19 Transmission in Kenya: A Model with Reinfection Transmission Mechanism |
title_short | Mathematical Modelling of COVID-19 Transmission in Kenya: A Model with Reinfection Transmission Mechanism |
title_sort | mathematical modelling of covid-19 transmission in kenya: a model with reinfection transmission mechanism |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8578696/ https://www.ncbi.nlm.nih.gov/pubmed/34777563 http://dx.doi.org/10.1155/2021/5384481 |
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