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Mathematical Modelling of COVID-19 Transmission in Kenya: A Model with Reinfection Transmission Mechanism

In this study we propose a Coronavirus Disease 2019 (COVID-19) mathematical model that stratifies infectious subpopulations into: infectious asymptomatic individuals, symptomatic infectious individuals who manifest mild symptoms and symptomatic individuals with severe symptoms. In light of the recen...

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Autores principales: Wangari, Isaac Mwangi, Sewe, Stanley, Kimathi, George, Wainaina, Mary, Kitetu, Virginia, Kaluki, Winnie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8578696/
https://www.ncbi.nlm.nih.gov/pubmed/34777563
http://dx.doi.org/10.1155/2021/5384481
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author Wangari, Isaac Mwangi
Sewe, Stanley
Kimathi, George
Wainaina, Mary
Kitetu, Virginia
Kaluki, Winnie
author_facet Wangari, Isaac Mwangi
Sewe, Stanley
Kimathi, George
Wainaina, Mary
Kitetu, Virginia
Kaluki, Winnie
author_sort Wangari, Isaac Mwangi
collection PubMed
description In this study we propose a Coronavirus Disease 2019 (COVID-19) mathematical model that stratifies infectious subpopulations into: infectious asymptomatic individuals, symptomatic infectious individuals who manifest mild symptoms and symptomatic individuals with severe symptoms. In light of the recent revelation that reinfection by COVID-19 is possible, the proposed model attempt to investigate how reinfection with COVID-19 will alter the future dynamics of the recent unfolding pandemic. Fitting the mathematical model on the Kenya COVID-19 dataset, model parameter values were obtained and used to conduct numerical simulations. Numerical results suggest that reinfection of recovered individuals who have lost their protective immunity will create a large pool of asymptomatic infectious individuals which will ultimately increase symptomatic individuals with mild symptoms and symptomatic individuals with severe symptoms (critically ill) needing urgent medical attention. The model suggests that reinfection with COVID-19 will lead to an increase in cumulative reported deaths. Comparison of the impact of non pharmaceutical interventions on curbing COVID19 proliferation suggests that wearing face masks profoundly reduce COVID-19 prevalence than maintaining social/physical distance. Further, numerical findings reveal that increasing detection rate of asymptomatic cases via contact tracing, testing and isolating them can drastically reduce COVID-19 surge, in particular individuals who are critically ill and require admission into intensive care.
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spelling pubmed-85786962021-11-11 Mathematical Modelling of COVID-19 Transmission in Kenya: A Model with Reinfection Transmission Mechanism Wangari, Isaac Mwangi Sewe, Stanley Kimathi, George Wainaina, Mary Kitetu, Virginia Kaluki, Winnie Comput Math Methods Med Research Article In this study we propose a Coronavirus Disease 2019 (COVID-19) mathematical model that stratifies infectious subpopulations into: infectious asymptomatic individuals, symptomatic infectious individuals who manifest mild symptoms and symptomatic individuals with severe symptoms. In light of the recent revelation that reinfection by COVID-19 is possible, the proposed model attempt to investigate how reinfection with COVID-19 will alter the future dynamics of the recent unfolding pandemic. Fitting the mathematical model on the Kenya COVID-19 dataset, model parameter values were obtained and used to conduct numerical simulations. Numerical results suggest that reinfection of recovered individuals who have lost their protective immunity will create a large pool of asymptomatic infectious individuals which will ultimately increase symptomatic individuals with mild symptoms and symptomatic individuals with severe symptoms (critically ill) needing urgent medical attention. The model suggests that reinfection with COVID-19 will lead to an increase in cumulative reported deaths. Comparison of the impact of non pharmaceutical interventions on curbing COVID19 proliferation suggests that wearing face masks profoundly reduce COVID-19 prevalence than maintaining social/physical distance. Further, numerical findings reveal that increasing detection rate of asymptomatic cases via contact tracing, testing and isolating them can drastically reduce COVID-19 surge, in particular individuals who are critically ill and require admission into intensive care. Hindawi 2021-10-16 /pmc/articles/PMC8578696/ /pubmed/34777563 http://dx.doi.org/10.1155/2021/5384481 Text en Copyright © 2021 Isaac Mwangi Wangari et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Wangari, Isaac Mwangi
Sewe, Stanley
Kimathi, George
Wainaina, Mary
Kitetu, Virginia
Kaluki, Winnie
Mathematical Modelling of COVID-19 Transmission in Kenya: A Model with Reinfection Transmission Mechanism
title Mathematical Modelling of COVID-19 Transmission in Kenya: A Model with Reinfection Transmission Mechanism
title_full Mathematical Modelling of COVID-19 Transmission in Kenya: A Model with Reinfection Transmission Mechanism
title_fullStr Mathematical Modelling of COVID-19 Transmission in Kenya: A Model with Reinfection Transmission Mechanism
title_full_unstemmed Mathematical Modelling of COVID-19 Transmission in Kenya: A Model with Reinfection Transmission Mechanism
title_short Mathematical Modelling of COVID-19 Transmission in Kenya: A Model with Reinfection Transmission Mechanism
title_sort mathematical modelling of covid-19 transmission in kenya: a model with reinfection transmission mechanism
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8578696/
https://www.ncbi.nlm.nih.gov/pubmed/34777563
http://dx.doi.org/10.1155/2021/5384481
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