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Repression precedes independent evolutionary gains of a highly specific gene expression pattern

Highly specific expression patterns can be caused by the overlapping activities of activator and repressor sequences in enhancers. However, few studies illuminate how these sequences evolve in the origin of new enhancers. Here, we show that expression of the bond gene in the semicircular wall epithe...

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Autores principales: Pu, Jian, Wang, Zinan, Cong, Haosu, Chin, Jacqueline S.R., Justen, Jessa, Finet, Cédric, Yew, Joanne Y., Chung, Henry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8578697/
https://www.ncbi.nlm.nih.gov/pubmed/34706247
http://dx.doi.org/10.1016/j.celrep.2021.109896
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author Pu, Jian
Wang, Zinan
Cong, Haosu
Chin, Jacqueline S.R.
Justen, Jessa
Finet, Cédric
Yew, Joanne Y.
Chung, Henry
author_facet Pu, Jian
Wang, Zinan
Cong, Haosu
Chin, Jacqueline S.R.
Justen, Jessa
Finet, Cédric
Yew, Joanne Y.
Chung, Henry
author_sort Pu, Jian
collection PubMed
description Highly specific expression patterns can be caused by the overlapping activities of activator and repressor sequences in enhancers. However, few studies illuminate how these sequences evolve in the origin of new enhancers. Here, we show that expression of the bond gene in the semicircular wall epithelium (swe) of the Drosophila melanogaster male ejaculatory bulb (EB) is controlled by an enhancer consisting of an activator region that requires Abdominal-B driving expression in the entire EB and a repressor region that restricts this expression to the EB swe. Although this expression pattern is independently gained in the distantly related Scaptodrosophila lebanonensis and does not require Abdominal-B, we show that functionally similar repressor sequences are present in Scaptodrosophila and also in species that do not express bond in the EB. We suggest that during enhancer evolution, repressor sequences can precede the evolution of activator sequences and may lead to similar but independently evolved expression patterns.
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spelling pubmed-85786972021-11-10 Repression precedes independent evolutionary gains of a highly specific gene expression pattern Pu, Jian Wang, Zinan Cong, Haosu Chin, Jacqueline S.R. Justen, Jessa Finet, Cédric Yew, Joanne Y. Chung, Henry Cell Rep Article Highly specific expression patterns can be caused by the overlapping activities of activator and repressor sequences in enhancers. However, few studies illuminate how these sequences evolve in the origin of new enhancers. Here, we show that expression of the bond gene in the semicircular wall epithelium (swe) of the Drosophila melanogaster male ejaculatory bulb (EB) is controlled by an enhancer consisting of an activator region that requires Abdominal-B driving expression in the entire EB and a repressor region that restricts this expression to the EB swe. Although this expression pattern is independently gained in the distantly related Scaptodrosophila lebanonensis and does not require Abdominal-B, we show that functionally similar repressor sequences are present in Scaptodrosophila and also in species that do not express bond in the EB. We suggest that during enhancer evolution, repressor sequences can precede the evolution of activator sequences and may lead to similar but independently evolved expression patterns. 2021-10-26 /pmc/articles/PMC8578697/ /pubmed/34706247 http://dx.doi.org/10.1016/j.celrep.2021.109896 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ).
spellingShingle Article
Pu, Jian
Wang, Zinan
Cong, Haosu
Chin, Jacqueline S.R.
Justen, Jessa
Finet, Cédric
Yew, Joanne Y.
Chung, Henry
Repression precedes independent evolutionary gains of a highly specific gene expression pattern
title Repression precedes independent evolutionary gains of a highly specific gene expression pattern
title_full Repression precedes independent evolutionary gains of a highly specific gene expression pattern
title_fullStr Repression precedes independent evolutionary gains of a highly specific gene expression pattern
title_full_unstemmed Repression precedes independent evolutionary gains of a highly specific gene expression pattern
title_short Repression precedes independent evolutionary gains of a highly specific gene expression pattern
title_sort repression precedes independent evolutionary gains of a highly specific gene expression pattern
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8578697/
https://www.ncbi.nlm.nih.gov/pubmed/34706247
http://dx.doi.org/10.1016/j.celrep.2021.109896
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