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Long Non-Coding RNA: A Potential Strategy for the Diagnosis and Treatment of Colorectal Cancer

Colorectal cancer (CRC), being one of the most commonly diagnosed cancers worldwide, endangers human health. Because the pathological mechanism of CRC is not fully understood, there are many challenges in the prevention, diagnosis, and treatment of this disease. Long non-coding RNAs (lncRNAs) have r...

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Autores principales: Chen, Shanshan, Fang, Yi, Sun, Lingyu, He, Ruonan, He, Beihui, Zhang, Shuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8578871/
https://www.ncbi.nlm.nih.gov/pubmed/34778084
http://dx.doi.org/10.3389/fonc.2021.762752
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author Chen, Shanshan
Fang, Yi
Sun, Lingyu
He, Ruonan
He, Beihui
Zhang, Shuo
author_facet Chen, Shanshan
Fang, Yi
Sun, Lingyu
He, Ruonan
He, Beihui
Zhang, Shuo
author_sort Chen, Shanshan
collection PubMed
description Colorectal cancer (CRC), being one of the most commonly diagnosed cancers worldwide, endangers human health. Because the pathological mechanism of CRC is not fully understood, there are many challenges in the prevention, diagnosis, and treatment of this disease. Long non-coding RNAs (lncRNAs) have recently drawn great attention for their potential roles in the different stages of CRC formation, invasion, and progression, including regulation of molecular signaling pathways, apoptosis, autophagy, angiogenesis, tumor metabolism, immunological responses, cell cycle, and epithelial-mesenchymal transition (EMT). This review aims to discuss the potential mechanisms of several oncogenic lncRNAs, as well as several suppressor lncRNAs, in CRC occurrence and development to aid in the discovery of new methods for CRC diagnosis, treatment, and prognosis assessment.
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spelling pubmed-85788712021-11-11 Long Non-Coding RNA: A Potential Strategy for the Diagnosis and Treatment of Colorectal Cancer Chen, Shanshan Fang, Yi Sun, Lingyu He, Ruonan He, Beihui Zhang, Shuo Front Oncol Oncology Colorectal cancer (CRC), being one of the most commonly diagnosed cancers worldwide, endangers human health. Because the pathological mechanism of CRC is not fully understood, there are many challenges in the prevention, diagnosis, and treatment of this disease. Long non-coding RNAs (lncRNAs) have recently drawn great attention for their potential roles in the different stages of CRC formation, invasion, and progression, including regulation of molecular signaling pathways, apoptosis, autophagy, angiogenesis, tumor metabolism, immunological responses, cell cycle, and epithelial-mesenchymal transition (EMT). This review aims to discuss the potential mechanisms of several oncogenic lncRNAs, as well as several suppressor lncRNAs, in CRC occurrence and development to aid in the discovery of new methods for CRC diagnosis, treatment, and prognosis assessment. Frontiers Media S.A. 2021-10-27 /pmc/articles/PMC8578871/ /pubmed/34778084 http://dx.doi.org/10.3389/fonc.2021.762752 Text en Copyright © 2021 Chen, Fang, Sun, He, He and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Chen, Shanshan
Fang, Yi
Sun, Lingyu
He, Ruonan
He, Beihui
Zhang, Shuo
Long Non-Coding RNA: A Potential Strategy for the Diagnosis and Treatment of Colorectal Cancer
title Long Non-Coding RNA: A Potential Strategy for the Diagnosis and Treatment of Colorectal Cancer
title_full Long Non-Coding RNA: A Potential Strategy for the Diagnosis and Treatment of Colorectal Cancer
title_fullStr Long Non-Coding RNA: A Potential Strategy for the Diagnosis and Treatment of Colorectal Cancer
title_full_unstemmed Long Non-Coding RNA: A Potential Strategy for the Diagnosis and Treatment of Colorectal Cancer
title_short Long Non-Coding RNA: A Potential Strategy for the Diagnosis and Treatment of Colorectal Cancer
title_sort long non-coding rna: a potential strategy for the diagnosis and treatment of colorectal cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8578871/
https://www.ncbi.nlm.nih.gov/pubmed/34778084
http://dx.doi.org/10.3389/fonc.2021.762752
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