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Long Non-Coding RNA: A Potential Strategy for the Diagnosis and Treatment of Colorectal Cancer
Colorectal cancer (CRC), being one of the most commonly diagnosed cancers worldwide, endangers human health. Because the pathological mechanism of CRC is not fully understood, there are many challenges in the prevention, diagnosis, and treatment of this disease. Long non-coding RNAs (lncRNAs) have r...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8578871/ https://www.ncbi.nlm.nih.gov/pubmed/34778084 http://dx.doi.org/10.3389/fonc.2021.762752 |
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author | Chen, Shanshan Fang, Yi Sun, Lingyu He, Ruonan He, Beihui Zhang, Shuo |
author_facet | Chen, Shanshan Fang, Yi Sun, Lingyu He, Ruonan He, Beihui Zhang, Shuo |
author_sort | Chen, Shanshan |
collection | PubMed |
description | Colorectal cancer (CRC), being one of the most commonly diagnosed cancers worldwide, endangers human health. Because the pathological mechanism of CRC is not fully understood, there are many challenges in the prevention, diagnosis, and treatment of this disease. Long non-coding RNAs (lncRNAs) have recently drawn great attention for their potential roles in the different stages of CRC formation, invasion, and progression, including regulation of molecular signaling pathways, apoptosis, autophagy, angiogenesis, tumor metabolism, immunological responses, cell cycle, and epithelial-mesenchymal transition (EMT). This review aims to discuss the potential mechanisms of several oncogenic lncRNAs, as well as several suppressor lncRNAs, in CRC occurrence and development to aid in the discovery of new methods for CRC diagnosis, treatment, and prognosis assessment. |
format | Online Article Text |
id | pubmed-8578871 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85788712021-11-11 Long Non-Coding RNA: A Potential Strategy for the Diagnosis and Treatment of Colorectal Cancer Chen, Shanshan Fang, Yi Sun, Lingyu He, Ruonan He, Beihui Zhang, Shuo Front Oncol Oncology Colorectal cancer (CRC), being one of the most commonly diagnosed cancers worldwide, endangers human health. Because the pathological mechanism of CRC is not fully understood, there are many challenges in the prevention, diagnosis, and treatment of this disease. Long non-coding RNAs (lncRNAs) have recently drawn great attention for their potential roles in the different stages of CRC formation, invasion, and progression, including regulation of molecular signaling pathways, apoptosis, autophagy, angiogenesis, tumor metabolism, immunological responses, cell cycle, and epithelial-mesenchymal transition (EMT). This review aims to discuss the potential mechanisms of several oncogenic lncRNAs, as well as several suppressor lncRNAs, in CRC occurrence and development to aid in the discovery of new methods for CRC diagnosis, treatment, and prognosis assessment. Frontiers Media S.A. 2021-10-27 /pmc/articles/PMC8578871/ /pubmed/34778084 http://dx.doi.org/10.3389/fonc.2021.762752 Text en Copyright © 2021 Chen, Fang, Sun, He, He and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Chen, Shanshan Fang, Yi Sun, Lingyu He, Ruonan He, Beihui Zhang, Shuo Long Non-Coding RNA: A Potential Strategy for the Diagnosis and Treatment of Colorectal Cancer |
title | Long Non-Coding RNA: A Potential Strategy for the Diagnosis and Treatment of Colorectal Cancer |
title_full | Long Non-Coding RNA: A Potential Strategy for the Diagnosis and Treatment of Colorectal Cancer |
title_fullStr | Long Non-Coding RNA: A Potential Strategy for the Diagnosis and Treatment of Colorectal Cancer |
title_full_unstemmed | Long Non-Coding RNA: A Potential Strategy for the Diagnosis and Treatment of Colorectal Cancer |
title_short | Long Non-Coding RNA: A Potential Strategy for the Diagnosis and Treatment of Colorectal Cancer |
title_sort | long non-coding rna: a potential strategy for the diagnosis and treatment of colorectal cancer |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8578871/ https://www.ncbi.nlm.nih.gov/pubmed/34778084 http://dx.doi.org/10.3389/fonc.2021.762752 |
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