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Derivation and Clinical Validation of a Redox-Driven Prognostic Signature for Colorectal Cancer

Colorectal cancer (CRC), a seriously threat that endangers public health, has a striking tendency to relapse and metastasize. Redox-related signaling pathways have recently been extensively studied in cancers. However, the study and potential role of redox in CRC remain unelucidated. We developed an...

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Autores principales: Dang, Qin, Liu, Zaoqu, Hu, Shengyun, Chen, Zhuang, Meng, Lingfang, Hu, Junhong, Wang, Guixian, Yuan, Weitang, Han, Xinwei, Li, Lifeng, Sun, Zhenqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8578893/
https://www.ncbi.nlm.nih.gov/pubmed/34778061
http://dx.doi.org/10.3389/fonc.2021.743703
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author Dang, Qin
Liu, Zaoqu
Hu, Shengyun
Chen, Zhuang
Meng, Lingfang
Hu, Junhong
Wang, Guixian
Yuan, Weitang
Han, Xinwei
Li, Lifeng
Sun, Zhenqiang
author_facet Dang, Qin
Liu, Zaoqu
Hu, Shengyun
Chen, Zhuang
Meng, Lingfang
Hu, Junhong
Wang, Guixian
Yuan, Weitang
Han, Xinwei
Li, Lifeng
Sun, Zhenqiang
author_sort Dang, Qin
collection PubMed
description Colorectal cancer (CRC), a seriously threat that endangers public health, has a striking tendency to relapse and metastasize. Redox-related signaling pathways have recently been extensively studied in cancers. However, the study and potential role of redox in CRC remain unelucidated. We developed and validated a risk model for prognosis and recurrence prediction in CRC patients via identifying gene signatures driven by redox-related signaling pathways. The redox-driven prognostic signature (RDPS) was demonstrated to be an independent risk factor for patient survival (including OS and RFS) in four public cohorts and one clinical in-house cohort. Additionally, there was an intimate association between the risk score and tumor immune infiltration, with higher risk score accompanied with less immune cell infiltration. In this study, we used redox-related factors as an entry point, which may provide a broader perspective for prognosis prediction in CRC and have the potential to provide more promising evidence for immunotherapy.
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spelling pubmed-85788932021-11-11 Derivation and Clinical Validation of a Redox-Driven Prognostic Signature for Colorectal Cancer Dang, Qin Liu, Zaoqu Hu, Shengyun Chen, Zhuang Meng, Lingfang Hu, Junhong Wang, Guixian Yuan, Weitang Han, Xinwei Li, Lifeng Sun, Zhenqiang Front Oncol Oncology Colorectal cancer (CRC), a seriously threat that endangers public health, has a striking tendency to relapse and metastasize. Redox-related signaling pathways have recently been extensively studied in cancers. However, the study and potential role of redox in CRC remain unelucidated. We developed and validated a risk model for prognosis and recurrence prediction in CRC patients via identifying gene signatures driven by redox-related signaling pathways. The redox-driven prognostic signature (RDPS) was demonstrated to be an independent risk factor for patient survival (including OS and RFS) in four public cohorts and one clinical in-house cohort. Additionally, there was an intimate association between the risk score and tumor immune infiltration, with higher risk score accompanied with less immune cell infiltration. In this study, we used redox-related factors as an entry point, which may provide a broader perspective for prognosis prediction in CRC and have the potential to provide more promising evidence for immunotherapy. Frontiers Media S.A. 2021-10-27 /pmc/articles/PMC8578893/ /pubmed/34778061 http://dx.doi.org/10.3389/fonc.2021.743703 Text en Copyright © 2021 Dang, Liu, Hu, Chen, Meng, Hu, Wang, Yuan, Han, Li and Sun https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Dang, Qin
Liu, Zaoqu
Hu, Shengyun
Chen, Zhuang
Meng, Lingfang
Hu, Junhong
Wang, Guixian
Yuan, Weitang
Han, Xinwei
Li, Lifeng
Sun, Zhenqiang
Derivation and Clinical Validation of a Redox-Driven Prognostic Signature for Colorectal Cancer
title Derivation and Clinical Validation of a Redox-Driven Prognostic Signature for Colorectal Cancer
title_full Derivation and Clinical Validation of a Redox-Driven Prognostic Signature for Colorectal Cancer
title_fullStr Derivation and Clinical Validation of a Redox-Driven Prognostic Signature for Colorectal Cancer
title_full_unstemmed Derivation and Clinical Validation of a Redox-Driven Prognostic Signature for Colorectal Cancer
title_short Derivation and Clinical Validation of a Redox-Driven Prognostic Signature for Colorectal Cancer
title_sort derivation and clinical validation of a redox-driven prognostic signature for colorectal cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8578893/
https://www.ncbi.nlm.nih.gov/pubmed/34778061
http://dx.doi.org/10.3389/fonc.2021.743703
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