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Inhibition of Poly ADP-Ribose Glycohydrolase Sensitizes Ovarian Cancer Cells to Poly ADP-Ribose Polymerase Inhibitors and Platinum Agents

BACKGROUND: Poly ADP-ribose glycohydrolase (PARG) is responsible for the catabolism of PARP-synthesized PAR to free ADP-ribose. Inhibition of PARG leads to DNA repair interruption and consequently induces cell death. This study aims to evaluate the effect of a PARG inhibitor (PARGi) on epithelial ov...

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Detalles Bibliográficos
Autores principales:	Matanes, Emad, López-Ozuna, Vanessa M., Octeau, David, Baloch, Tahira, Racovitan, Florentin, Dhillon, Amandeep Kaur, Kessous, Roy, Raban, Oded, Kogan, Liron, Salvador, Shannon, Lau, Susie, Gotlieb, Walter H., Yasmeen, Amber
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8578901/ https://www.ncbi.nlm.nih.gov/pubmed/34778062 http://dx.doi.org/10.3389/fonc.2021.745981

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