DSS-induced inflammation in the colon drives a proinflammatory signature in the brain that is ameliorated by prophylactic treatment with the S100A9 inhibitor paquinimod

BACKGROUND: Inflammatory bowel disease (IBD) is established to drive pathological sequelae in organ systems outside the intestine, including the central nervous system (CNS). Many patients exhibit cognitive deficits, particularly during disease flare. The connection between colonic inflammation and...

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Detalles Bibliográficos
Autores principales: Talley, Sarah, Valiauga, Rasa, Anderson, Lillian, Cannon, Abigail R., Choudhry, Mashkoor A., Campbell, Edward M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8578918/
https://www.ncbi.nlm.nih.gov/pubmed/34758843
http://dx.doi.org/10.1186/s12974-021-02317-6

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