DPP inhibition alters the CXCR3 axis and enhances NK and CD8+ T cell infiltration to improve anti-PD1 efficacy in murine models of pancreatic ductal adenocarcinoma

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is projected to be the second leading cause of cancer death in the USA by 2030. Immune checkpoint inhibitors fail to control most PDAC tumors because of PDAC’s extensive immunosuppressive microenvironment and poor immune infiltration, a phenotype a...

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Detalles Bibliográficos
Autores principales: Fitzgerald, Allison A, Wang, Shangzi, Agarwal, Veena, Marcisak, Emily F, Zuo, Annie, Jablonski, Sandra A, Loth, Melanie, Fertig, Elana J, MacDougall, John, Zhukovsky, Eugene, Trivedi, Shubhendu, Bhatia, Dimple, O'Neill, Vince, Weiner, Louis M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8578994/
https://www.ncbi.nlm.nih.gov/pubmed/34737215
http://dx.doi.org/10.1136/jitc-2021-002837

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8578994/
https://www.ncbi.nlm.nih.gov/pubmed/34737215
http://dx.doi.org/10.1136/jitc-2021-002837

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