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Pilocytic Astrocytoma-Derived Cells in Peripheral Blood: A Case Report

Imaging limitations, invasive tissue biopsies and poor information over the course of treatment to evaluate ‘real-time’ tumor dynamics justify the emerging use of liquid biopsies in the field of brain tumors. Circulating tumor cells (CTCs) from high-grade astrocytomas might reach the circulation by...

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Autores principales: Volpentesta, Giorgio, Donato, Giuseppe, Ferraro, Elisabetta, Mignogna, Chiara, Radaelli, Riccardo, Sabatini, Umberto, La Torre, Domenico, Malara, Natalia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8579051/
https://www.ncbi.nlm.nih.gov/pubmed/34778052
http://dx.doi.org/10.3389/fonc.2021.737730
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author Volpentesta, Giorgio
Donato, Giuseppe
Ferraro, Elisabetta
Mignogna, Chiara
Radaelli, Riccardo
Sabatini, Umberto
La Torre, Domenico
Malara, Natalia
author_facet Volpentesta, Giorgio
Donato, Giuseppe
Ferraro, Elisabetta
Mignogna, Chiara
Radaelli, Riccardo
Sabatini, Umberto
La Torre, Domenico
Malara, Natalia
author_sort Volpentesta, Giorgio
collection PubMed
description Imaging limitations, invasive tissue biopsies and poor information over the course of treatment to evaluate ‘real-time’ tumor dynamics justify the emerging use of liquid biopsies in the field of brain tumors. Circulating tumor cells (CTCs) from high-grade astrocytomas might reach the circulation by crossing the blood–brain barrier. Here, for the first time, CTCs cytology in a case of pylocitic astrocytoma is described. An obstructive hydrocephalous due to a lateral mesencephalic tectum mass occluding the Silvio Aqueduct was diagnosed in a young, 18 years old, male. Considering the location of the tumor and the rapid deterioration of the neurological status, it has been decided to urgency treat the patient with ventriculoperitoneal shunting. Magnetic resonance imaging showed a nodular shaped lesion localized within the left lateral mesencephalic tectum. Stereotactic biopsy was not approachable due significant risk of neurological consequences. The diagnosis was performed by blood sampling, a non-invasive procedure for the patient, in order to provide tumor information. Cytopathological features on detected circulating atypical GFAP positive cells led to pilocytic diagnosis confirmed by the patient’s 68 months outcome.
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spelling pubmed-85790512021-11-11 Pilocytic Astrocytoma-Derived Cells in Peripheral Blood: A Case Report Volpentesta, Giorgio Donato, Giuseppe Ferraro, Elisabetta Mignogna, Chiara Radaelli, Riccardo Sabatini, Umberto La Torre, Domenico Malara, Natalia Front Oncol Oncology Imaging limitations, invasive tissue biopsies and poor information over the course of treatment to evaluate ‘real-time’ tumor dynamics justify the emerging use of liquid biopsies in the field of brain tumors. Circulating tumor cells (CTCs) from high-grade astrocytomas might reach the circulation by crossing the blood–brain barrier. Here, for the first time, CTCs cytology in a case of pylocitic astrocytoma is described. An obstructive hydrocephalous due to a lateral mesencephalic tectum mass occluding the Silvio Aqueduct was diagnosed in a young, 18 years old, male. Considering the location of the tumor and the rapid deterioration of the neurological status, it has been decided to urgency treat the patient with ventriculoperitoneal shunting. Magnetic resonance imaging showed a nodular shaped lesion localized within the left lateral mesencephalic tectum. Stereotactic biopsy was not approachable due significant risk of neurological consequences. The diagnosis was performed by blood sampling, a non-invasive procedure for the patient, in order to provide tumor information. Cytopathological features on detected circulating atypical GFAP positive cells led to pilocytic diagnosis confirmed by the patient’s 68 months outcome. Frontiers Media S.A. 2021-10-27 /pmc/articles/PMC8579051/ /pubmed/34778052 http://dx.doi.org/10.3389/fonc.2021.737730 Text en Copyright © 2021 Volpentesta, Donato, Ferraro, Mignogna, Radaelli, Sabatini, La Torre and Malara https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Volpentesta, Giorgio
Donato, Giuseppe
Ferraro, Elisabetta
Mignogna, Chiara
Radaelli, Riccardo
Sabatini, Umberto
La Torre, Domenico
Malara, Natalia
Pilocytic Astrocytoma-Derived Cells in Peripheral Blood: A Case Report
title Pilocytic Astrocytoma-Derived Cells in Peripheral Blood: A Case Report
title_full Pilocytic Astrocytoma-Derived Cells in Peripheral Blood: A Case Report
title_fullStr Pilocytic Astrocytoma-Derived Cells in Peripheral Blood: A Case Report
title_full_unstemmed Pilocytic Astrocytoma-Derived Cells in Peripheral Blood: A Case Report
title_short Pilocytic Astrocytoma-Derived Cells in Peripheral Blood: A Case Report
title_sort pilocytic astrocytoma-derived cells in peripheral blood: a case report
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8579051/
https://www.ncbi.nlm.nih.gov/pubmed/34778052
http://dx.doi.org/10.3389/fonc.2021.737730
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