Activated PI3Kδ syndrome, an immunodeficiency disorder, leads to sensorimotor deficits recapitulated in a murine model

The phosphoinositide-3-kinase (PI3K) family plays a major role in cell signaling and is predominant in leukocytes. Gain-of-function (GOF) mutations in the PIK3CD gene lead to the development of activated PI3Kδ syndrome (APDS), a rare primary immunodeficiency disorder. A subset of APDS patients also...

Descripción completa

Detalles Bibliográficos
Autores principales: Serra, Ines, Manusama, Olivia R., Kaiser, Fabian M.P., Floriano, Izi Izumi, Wahl, Lucas, van der Zalm, Christian, IJspeert, Hanna, van Hagen, P. Martin, van Beveren, Nico J.M., Arend, Sandra M., Okkenhaug, Klaus, Pel, Johan J.M., Dalm, Virgil A.S.H., Badura, Aleksandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Full Length Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8579111/
https://www.ncbi.nlm.nih.gov/pubmed/34786564
http://dx.doi.org/10.1016/j.bbih.2021.100377

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8579111/
https://www.ncbi.nlm.nih.gov/pubmed/34786564
http://dx.doi.org/10.1016/j.bbih.2021.100377

Ejemplares similares