α-Ketoglutarate Inhibits Thrombosis and Inflammation by Prolyl Hydroxylase-2 Mediated Inactivation of Phospho-Akt

BACKGROUND: Phospho-Akt1 (pAkt1) undergoes prolyl hydroxylation at Pro125 and Pro313 by the prolyl hydroxylase-2 (PHD2) in a reaction decarboxylating α-ketoglutarate (αKG). We investigated whether the αKG supplementation could inhibit Akt-mediated activation of platelets and monocytes, in vitro as w...

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Detalles Bibliográficos
Autores principales: Shrimali, Nishith M, Agarwal, Sakshi, Kaur, Simrandeep, Bhattacharya, Sulagna, Bhattacharyya, Sankar, Prchal, Josef T, Guchhait, Prasenjit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8579134/
https://www.ncbi.nlm.nih.gov/pubmed/34740102
http://dx.doi.org/10.1016/j.ebiom.2021.103672

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