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Role of interferon regulatory factor-mediated signaling in psoriasis

Psoriasis is a chronic inflammatory disease that involves both the innate and adaptive immune systems. Type I interferons (IFNs), the production of which is partially regulated by toll-like receptors (TLRs), play an important role in the pathogenesis of psoriasis, especially psoriasis caused by skin...

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Autores principales: Wang, Wen-Ming, Li, Feng, Jin, Hong-Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8579288/
https://www.ncbi.nlm.nih.gov/pubmed/34790055
http://dx.doi.org/10.7150/ijms.61973
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author Wang, Wen-Ming
Li, Feng
Jin, Hong-Zhong
author_facet Wang, Wen-Ming
Li, Feng
Jin, Hong-Zhong
author_sort Wang, Wen-Ming
collection PubMed
description Psoriasis is a chronic inflammatory disease that involves both the innate and adaptive immune systems. Type I interferons (IFNs), the production of which is partially regulated by toll-like receptors (TLRs), play an important role in the pathogenesis of psoriasis, especially psoriasis caused by skin trauma, known as the Koebner phenomenon. IFN regulatory factors (IRFs) function in both innate and adaptive immune responses, and their effect is associated with the regulation of type I IFNs. In this review, we focus on recent advances in understanding the expression of TLRs, IRFs, and type I IFNs in psoriasis. We also highlight the interplay among TLRs, IRFs, and type I IFNs.
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spelling pubmed-85792882021-11-16 Role of interferon regulatory factor-mediated signaling in psoriasis Wang, Wen-Ming Li, Feng Jin, Hong-Zhong Int J Med Sci Review Psoriasis is a chronic inflammatory disease that involves both the innate and adaptive immune systems. Type I interferons (IFNs), the production of which is partially regulated by toll-like receptors (TLRs), play an important role in the pathogenesis of psoriasis, especially psoriasis caused by skin trauma, known as the Koebner phenomenon. IFN regulatory factors (IRFs) function in both innate and adaptive immune responses, and their effect is associated with the regulation of type I IFNs. In this review, we focus on recent advances in understanding the expression of TLRs, IRFs, and type I IFNs in psoriasis. We also highlight the interplay among TLRs, IRFs, and type I IFNs. Ivyspring International Publisher 2021-10-16 /pmc/articles/PMC8579288/ /pubmed/34790055 http://dx.doi.org/10.7150/ijms.61973 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Wang, Wen-Ming
Li, Feng
Jin, Hong-Zhong
Role of interferon regulatory factor-mediated signaling in psoriasis
title Role of interferon regulatory factor-mediated signaling in psoriasis
title_full Role of interferon regulatory factor-mediated signaling in psoriasis
title_fullStr Role of interferon regulatory factor-mediated signaling in psoriasis
title_full_unstemmed Role of interferon regulatory factor-mediated signaling in psoriasis
title_short Role of interferon regulatory factor-mediated signaling in psoriasis
title_sort role of interferon regulatory factor-mediated signaling in psoriasis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8579288/
https://www.ncbi.nlm.nih.gov/pubmed/34790055
http://dx.doi.org/10.7150/ijms.61973
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