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The Emerging Roles of π Subunit-Containing GABA(A) Receptors in Different Cancers

Cancer is one of the leading causes of death in both developed and developing countries. Due to its heterogenous nature, it occurs in various regions of the body and often goes undetected until later stages of disease progression. Feasible treatment options are limited because of the invasive nature...

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Autores principales: JUVALE, Iman Imtiyaz Ahmed, HASSAN, Zurina, HAS, Ahmad Tarmizi CHE
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8579298/
https://www.ncbi.nlm.nih.gov/pubmed/34790061
http://dx.doi.org/10.7150/ijms.60928
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author JUVALE, Iman Imtiyaz Ahmed
HASSAN, Zurina
HAS, Ahmad Tarmizi CHE
author_facet JUVALE, Iman Imtiyaz Ahmed
HASSAN, Zurina
HAS, Ahmad Tarmizi CHE
author_sort JUVALE, Iman Imtiyaz Ahmed
collection PubMed
description Cancer is one of the leading causes of death in both developed and developing countries. Due to its heterogenous nature, it occurs in various regions of the body and often goes undetected until later stages of disease progression. Feasible treatment options are limited because of the invasive nature of cancer and often result in detrimental side-effects and poor survival rates. Therefore, recent studies have attempted to identify aberrant expression levels of previously undiscovered proteins in cancer, with the hope of developing better diagnostic tools and pharmaceutical options. One class of such targets is the π-subunit-containing γ-aminobutyric acid type A receptors. Although these receptors were discovered more than 20 years ago, there is limited information available. They possess atypical functional properties and are expressed in several non-neuronal tissues. Prior studies have highlighted the role of these receptors in the female reproductive system. New research focusing on the higher expression levels of these receptors in ovarian, breast, gastric, cervical, and pancreatic cancers, their physiological function in healthy individuals, and their pro-tumorigenic effects in these cancer types is reviewed here.
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spelling pubmed-85792982021-11-16 The Emerging Roles of π Subunit-Containing GABA(A) Receptors in Different Cancers JUVALE, Iman Imtiyaz Ahmed HASSAN, Zurina HAS, Ahmad Tarmizi CHE Int J Med Sci Review Cancer is one of the leading causes of death in both developed and developing countries. Due to its heterogenous nature, it occurs in various regions of the body and often goes undetected until later stages of disease progression. Feasible treatment options are limited because of the invasive nature of cancer and often result in detrimental side-effects and poor survival rates. Therefore, recent studies have attempted to identify aberrant expression levels of previously undiscovered proteins in cancer, with the hope of developing better diagnostic tools and pharmaceutical options. One class of such targets is the π-subunit-containing γ-aminobutyric acid type A receptors. Although these receptors were discovered more than 20 years ago, there is limited information available. They possess atypical functional properties and are expressed in several non-neuronal tissues. Prior studies have highlighted the role of these receptors in the female reproductive system. New research focusing on the higher expression levels of these receptors in ovarian, breast, gastric, cervical, and pancreatic cancers, their physiological function in healthy individuals, and their pro-tumorigenic effects in these cancer types is reviewed here. Ivyspring International Publisher 2021-10-31 /pmc/articles/PMC8579298/ /pubmed/34790061 http://dx.doi.org/10.7150/ijms.60928 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
JUVALE, Iman Imtiyaz Ahmed
HASSAN, Zurina
HAS, Ahmad Tarmizi CHE
The Emerging Roles of π Subunit-Containing GABA(A) Receptors in Different Cancers
title The Emerging Roles of π Subunit-Containing GABA(A) Receptors in Different Cancers
title_full The Emerging Roles of π Subunit-Containing GABA(A) Receptors in Different Cancers
title_fullStr The Emerging Roles of π Subunit-Containing GABA(A) Receptors in Different Cancers
title_full_unstemmed The Emerging Roles of π Subunit-Containing GABA(A) Receptors in Different Cancers
title_short The Emerging Roles of π Subunit-Containing GABA(A) Receptors in Different Cancers
title_sort emerging roles of π subunit-containing gaba(a) receptors in different cancers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8579298/
https://www.ncbi.nlm.nih.gov/pubmed/34790061
http://dx.doi.org/10.7150/ijms.60928
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