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The BUILT study: a single-center 5-year experience of Lung Cancer screening in Taiwan

Background: There are no uniform guidelines on low-dose computed tomography (LDCT) follow-up in lung cancer screening. Few studies have analyzed the incidental abnormalities and role of tumor markers in lung cancer screening. The purpose of this study was to investigate the diagnostic performance of...

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Autores principales: Wu, Chih-Wei, Ku, Yen-Te, Huang, Chun-Yao, Hsieh, Po-Chun, Lim, Kun-Eng, Tzeng, I-Shiang, Lan, Chou-Chin, Wu, Yao-Kuang, Hsu, Yi-Chiung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8579303/
https://www.ncbi.nlm.nih.gov/pubmed/34790062
http://dx.doi.org/10.7150/ijms.64648
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author Wu, Chih-Wei
Ku, Yen-Te
Huang, Chun-Yao
Hsieh, Po-Chun
Lim, Kun-Eng
Tzeng, I-Shiang
Lan, Chou-Chin
Wu, Yao-Kuang
Hsu, Yi-Chiung
author_facet Wu, Chih-Wei
Ku, Yen-Te
Huang, Chun-Yao
Hsieh, Po-Chun
Lim, Kun-Eng
Tzeng, I-Shiang
Lan, Chou-Chin
Wu, Yao-Kuang
Hsu, Yi-Chiung
author_sort Wu, Chih-Wei
collection PubMed
description Background: There are no uniform guidelines on low-dose computed tomography (LDCT) follow-up in lung cancer screening. Few studies have analyzed the incidental abnormalities and role of tumor markers in lung cancer screening. The purpose of this study was to investigate the diagnostic performance of LDCT, optimal follow-up duration, incidental findings, and role of tumor markers in diagnosing lung cancer. Methods: We retrospectively analyzed subjects who underwent their first LDCT in Taipei Tzu Chi Hospital between September 1, 2015, and August 31, 2016. All chest CT scans until August 31, 2020, were recorded. A non-calcified nodule with a diameter ≥2 mm on LDCT was defined as a positive result. We extracted the data, including possible risk factors of lung cancer and follow-up outcomes. Results: A total of 1502 subjects were recruited. Of the 38 subjects who underwent biopsy, 31 had confirmed lung cancer. Lung cancer in all patients was diagnosed within 4 years. Univariate logistic regression analysis revealed that a family history of lung cancer in first-degree relatives and abnormal serum carcinoembryonic antigen (CEA) levels were the significant risk factors for lung cancer. A cumulative lung cancer incidence of 54.7 patients per 1000 person-years was determined solely via radiological follow-up. In total, 271 (18%) subjects exhibited incidental findings on baseline LDCT. Conclusion: The overall lung cancer detection rate in this study was 2.1% in the 5-year study period. A family history of lung cancer and abnormal serum CEA levels are important risk factors for lung cancer. A minimum of 4-year follow-up is required to track suspicious nodules. A purely radiological follow-up detects a high incidence of lung cancer.
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spelling pubmed-85793032021-11-16 The BUILT study: a single-center 5-year experience of Lung Cancer screening in Taiwan Wu, Chih-Wei Ku, Yen-Te Huang, Chun-Yao Hsieh, Po-Chun Lim, Kun-Eng Tzeng, I-Shiang Lan, Chou-Chin Wu, Yao-Kuang Hsu, Yi-Chiung Int J Med Sci Research Paper Background: There are no uniform guidelines on low-dose computed tomography (LDCT) follow-up in lung cancer screening. Few studies have analyzed the incidental abnormalities and role of tumor markers in lung cancer screening. The purpose of this study was to investigate the diagnostic performance of LDCT, optimal follow-up duration, incidental findings, and role of tumor markers in diagnosing lung cancer. Methods: We retrospectively analyzed subjects who underwent their first LDCT in Taipei Tzu Chi Hospital between September 1, 2015, and August 31, 2016. All chest CT scans until August 31, 2020, were recorded. A non-calcified nodule with a diameter ≥2 mm on LDCT was defined as a positive result. We extracted the data, including possible risk factors of lung cancer and follow-up outcomes. Results: A total of 1502 subjects were recruited. Of the 38 subjects who underwent biopsy, 31 had confirmed lung cancer. Lung cancer in all patients was diagnosed within 4 years. Univariate logistic regression analysis revealed that a family history of lung cancer in first-degree relatives and abnormal serum carcinoembryonic antigen (CEA) levels were the significant risk factors for lung cancer. A cumulative lung cancer incidence of 54.7 patients per 1000 person-years was determined solely via radiological follow-up. In total, 271 (18%) subjects exhibited incidental findings on baseline LDCT. Conclusion: The overall lung cancer detection rate in this study was 2.1% in the 5-year study period. A family history of lung cancer and abnormal serum CEA levels are important risk factors for lung cancer. A minimum of 4-year follow-up is required to track suspicious nodules. A purely radiological follow-up detects a high incidence of lung cancer. Ivyspring International Publisher 2021-10-31 /pmc/articles/PMC8579303/ /pubmed/34790062 http://dx.doi.org/10.7150/ijms.64648 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Wu, Chih-Wei
Ku, Yen-Te
Huang, Chun-Yao
Hsieh, Po-Chun
Lim, Kun-Eng
Tzeng, I-Shiang
Lan, Chou-Chin
Wu, Yao-Kuang
Hsu, Yi-Chiung
The BUILT study: a single-center 5-year experience of Lung Cancer screening in Taiwan
title The BUILT study: a single-center 5-year experience of Lung Cancer screening in Taiwan
title_full The BUILT study: a single-center 5-year experience of Lung Cancer screening in Taiwan
title_fullStr The BUILT study: a single-center 5-year experience of Lung Cancer screening in Taiwan
title_full_unstemmed The BUILT study: a single-center 5-year experience of Lung Cancer screening in Taiwan
title_short The BUILT study: a single-center 5-year experience of Lung Cancer screening in Taiwan
title_sort built study: a single-center 5-year experience of lung cancer screening in taiwan
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8579303/
https://www.ncbi.nlm.nih.gov/pubmed/34790062
http://dx.doi.org/10.7150/ijms.64648
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